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Proposed model for PTN-stimulated dissociation of β-adducin from F-actin and spectrin. Modified from Bennet and Bainnes (32). β-Adducin forms complexes between spectrin and actin promoting the association of spectrin with actin filaments. Pleiotrophin-induced phosphorylation of serines 713 and 726 β-adducin reduces the affinity of β-adducin for filamentous actin dissociating these cytoskeletal structures and increasing cleavage of β-adducin by caspase-3 and degradation of β-adducin.
