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. 2005 Aug 30;102(35):12644. doi: 10.1073/pnas.0505943102

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Fig. 3. — Electrophysiological studies with connexin-mimetic peptides. (A) Whole-cell patch-clamp recordings and histogram confirming that 600 μM ^37,40Gap 26 and 100 μM ⁴³Gap 26 did not depress endothelial hyperpolarizations evoked by 30 μM CPA. (B and C) Original recordings and histograms comparing the effects of the peptides and 2,000 units/ml catalase on subintimal (B) and subadventitial (C) hyperpolarizations evoked by CPA. ^37,40Gap 26 attenuated the transmission of endothelial hyperpolarization to subintimal smooth muscle, whereas ⁴³Gap 26 selectively impaired transmission of subintimal hyperpolarization across the vessel wall. The effects of both peptides were prevented by 100 μM 5-MTHF and (6R)-BH₄ but not by 100 μM FA or BH₂. Catalase prevented the effects of ^37,40Gap 26 on subintimal hyperpolarization, but not those of ⁴³Gap 26 on subadventitial hyperpolarization. ^*, P < 0.05, compared with control.