Fig. 5.

Subtle differences in unitary IPSCs in L5 pyramids of 4- to 5-week-old Mecp2 mutant mice. mIPSCs recorded from L5 pyramidal cells in the presence of APV, DNQX, and TTX. (A) Sample traces from WT and mutant cells voltage-clamped at -70 mV. (B) Averaged mIPSC from 17 WT and 17 mutant cells. The slightly increased mIPSC amplitude in mutant cells was not statistically significant across cells (C) (P = 0.23, t test), although the cumulative histograms of events from WT and mutant cells (D) showed a skew toward larger amplitudes that was highly significant. There was no significant change in the mean mIPSC frequency (E) and a small but significant change in the mean decay time constant (Table 1).