Table 2.

Plasma concentrations of sex hormone binding globulin and risk of fracture

	No of participants with fracture / person-years	Univariable		Multivariable Model 1		Multivariable Model 2
		Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Fracture - total population (n=4781)
SHBG quartile 1	92/4785	1.00 (ref)		1.00 (ref)		1.00 (ref)
SHBG quartile 2	107/4715	1.17 (0.89, 1.55)	0.26	1.13 (0.85, 1.51)	0.39	1.10 (0.82, 1.46)	0.52
SHBG quartile 3	121/4681	1.33 (1.02, 1.75)	0.04	1.25 (0.94, 1.66)	0.12	1.18 (0.89, 1.57)	0.26
SHBG quartile 4	164/4565	1.86 (1.44, 2.40)	<0.001	1.63 (1.23, 2.16)	0.001	1.54 (1.16, 2.04)	0.003
P for trend			<0.001		<0.001		0.001
Fracture - excluding women on medication affecting bone structure or mineralization (n=4199)
SHBG quartile 1	77/4402	1.00 (ref)		1.00 (ref)		1.00 (ref)
SHBG quartile 2	90/4222	1.21 (0.90, 1.65)	0.21	1.16 (0.85, 1.58)	0.36	1.12 (0.82, 1.53)	0.47
SHBG quartile 3	107/4104	1.48 (1.10, 1.98)	0.01	1.38 (1.01, 1.87)	0.04	1.30 (0.95, 1.78)	0.10
SHBG quartile 4	128/3752	1.95 (1.47, 2.58)	<0.001	1.72 (1.26, 2.33)	0.001	1.63 (1.19, 2.23)	0.002
P for trend			<0.001		<0.001		0.001
Minimal trauma fracture (n=4781)
SHBG quartile 1	76/4785	1.00 (ref)		1.00 (ref)		1.00 (ref)
SHBG quartile 2	80/4715	1.06 (0.78, 1.45)	0.71	1.02 (0.74, 1.40)	0.91	0.99 (0.72, 1.36)	0.94
SHBG quartile 3	104/4681	1.39 (1.03, 1.86)	0.03	1.23 (0.90, 1.67)	0.34	1.14 (0.83, 1.57)	0.41
SHBG quartile 4	132/4565	1.81 (1.37, 2.40)	<0.001	1.44 (1.05, 1.96)	0.02	1.37 (0.998, 1.87)	0.052
P for trend			<0.001		0.01		0.04

CI: confidence interval; SHBG: sex hormone binding globulin

Model 1: Adjusted for age, body mass index, alcohol consumption, smoking status, diabetes, impaired renal function, treatment allocation (aspirin/placebo), and medication affecting bone structure or mineralization

Model 2: Model 1 + high-density lipoprotein cholesterol