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. 2024 Nov 26;46(4):989–1001. doi: 10.1038/s41401-024-01423-4

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 2 — a The efficiency of rAAV9 adeno-associated virus-mediated ASIC1a knockdown in the liver of mice was examined by observing EGFP. b Immunohistochemistry analysis of ASIC1a expression in mouse liver tissues after ASIC1a knockdown in ALD. c The protein level of ASIC1a in mouse primary hepatocytes after ASIC1a knockdown in ALD. d The protein level of ASIC1a in mouse liver tissues after ASIC1a knockdown in ALD. e The mRNA level of ASIC1a in mouse primary hepatocytes after ASIC1a knockdown in ALD. f The mRNA level of ASIC1a in mouse liver tissues after ASIC1a knockdown in ALD. g Serum markers, including AST, ALT and TG, were measured after ASIC1a knockdown in ALD. h, i Representative hematoxylin and eosin (H&E) staining and Oil red O staining of liver tissues after ASIC1a knockdown in ALD. Western blot bands are not from same membrane. *P < 0.05, ***P < 0.001, ****P<0.0001 vs EtOH-fed+rAAV9-Vector group.