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. 1993 Oct;69(5):333–340. doi: 10.1136/sti.69.5.333

The pathogenesis of the neurological complications of HIV-1 infection.

B J Brew 1
PMCID: PMC1195113  PMID: 8244348

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Achim C. L., Morey M. K., Wiley C. A. Expression of major histocompatibility complex and HIV antigens within the brains of AIDS patients. AIDS. 1991 May;5(5):535–541. doi: 10.1097/00002030-199105000-00009. [DOI] [PubMed] [Google Scholar]
  2. Achim C. L., Schrier R. D., Wiley C. A. Immunopathogenesis of HIV encephalitis. Brain Pathol. 1991 Apr;1(3):177–184. doi: 10.1111/j.1750-3639.1991.tb00657.x. [DOI] [PubMed] [Google Scholar]
  3. Boucher C. A., Lange J. M., Miedema F. F., Weverling G. J., Koot M., Mulder J. W., Goudsmit J., Kellam P., Larder B. A., Tersmette M. HIV-1 biological phenotype and the development of zidovudine resistance in relation to disease progression in asymptomatic individuals during treatment. AIDS. 1992 Nov;6(11):1259–1264. doi: 10.1097/00002030-199211000-00003. [DOI] [PubMed] [Google Scholar]
  4. Brenneman D. E., Westbrook G. L., Fitzgerald S. P., Ennist D. L., Elkins K. L., Ruff M. R., Pert C. B. Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide. Nature. 1988 Oct 13;335(6191):639–642. doi: 10.1038/335639a0. [DOI] [PubMed] [Google Scholar]
  5. Brew B. J., Bhalla R. B., Paul M., Gallardo H., McArthur J. C., Schwartz M. K., Price R. W. Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection. Ann Neurol. 1990 Oct;28(4):556–560. doi: 10.1002/ana.410280413. [DOI] [PubMed] [Google Scholar]
  6. Brew B. J., Bhalla R. B., Paul M., Sidtis J. J., Keilp J. J., Sadler A. E., Gallardo H., McArthur J. C., Schwartz M. K., Price R. W. Cerebrospinal fluid beta 2-microglobulin in patients with AIDS dementia complex: an expanded series including response to zidovudine treatment. AIDS. 1992 May;6(5):461–465. [PubMed] [Google Scholar]
  7. Brew B. J., Hardy W., Zuckerman E., Chien N., Paul M., Rosenblum M., Gadler H., Vahlne A., Gold J., Armstrong D. A. AIDS-related vacuolar myelopathy is not associated with coinfection by human T-lymphotropic virus type I. Ann Neurol. 1989 Nov;26(5):679–681. doi: 10.1002/ana.410260515. [DOI] [PubMed] [Google Scholar]
  8. Brew B. J., Miller J. Human immunodeficiency virus-related headache. Neurology. 1993 Jun;43(6):1098–1100. doi: 10.1212/wnl.43.6.1098. [DOI] [PubMed] [Google Scholar]
  9. Brinkmann R., Schwinn A., Narayan O., Zink C., Kreth H. W., Roggendorf W., Dörries R., Schwender S., Imrich H., ter Meulen V. Human immunodeficiency virus infection in microglia: correlation between cells infected in the brain and cells cultured from infectious brain tissue. Ann Neurol. 1992 Apr;31(4):361–365. doi: 10.1002/ana.410310403. [DOI] [PubMed] [Google Scholar]
  10. Budka H., Maier H., Pohl P. Human immunodeficiency virus in vacuolar myelopathy of the acquired immunodeficiency syndrome. N Engl J Med. 1988 Dec 22;319(25):1667–1668. doi: 10.1056/NEJM198812223192511. [DOI] [PubMed] [Google Scholar]
  11. Budka H., Wiley C. A., Kleihues P., Artigas J., Asbury A. K., Cho E. S., Cornblath D. R., Dal Canto M. C., DeGirolami U., Dickson D. HIV-associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology. Brain Pathol. 1991 Apr;1(3):143–152. doi: 10.1111/j.1750-3639.1991.tb00653.x. [DOI] [PubMed] [Google Scholar]
  12. Cheng-Mayer C., Weiss C., Seto D., Levy J. A. Isolates of human immunodeficiency virus type 1 from the brain may constitute a special group of the AIDS virus. Proc Natl Acad Sci U S A. 1989 Nov;86(21):8575–8579. doi: 10.1073/pnas.86.21.8575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Chiodi F., Albert J., Olausson E., Norkrans G., Hagberg L., Sönnerborg A., Asjö B., Fenyö E. M. Isolation frequency of human immunodeficiency virus from cerebrospinal fluid and blood of patients with varying severity of HIV infection. AIDS Res Hum Retroviruses. 1988 Oct;4(5):351–358. doi: 10.1089/aid.1988.4.351. [DOI] [PubMed] [Google Scholar]
  14. Chiodi F., Sönnerborg A., Albert J., Gaines H., Norkrans G., Hagberg L., Asjö B., Strannegård O., Fenyö E. M. Human immunodeficiency virus infection of the brain. I. Virus isolation and detection of HIV specific antibodies in the cerebrospinal fluid of patients with varying clinical conditions. J Neurol Sci. 1988 Jul;85(3):245–257. doi: 10.1016/0022-510x(88)90184-0. [DOI] [PubMed] [Google Scholar]
  15. Christofinis G., Papadaki L., Sattentau Q., Ferns R. B., Tedder R. HIV replicates in cultured human brain cells. AIDS. 1987 Dec;1(4):229–234. [PubMed] [Google Scholar]
  16. Clapham P. R., Weber J. N., Whitby D., McIntosh K., Dalgleish A. G., Maddon P. J., Deen K. C., Sweet R. W., Weiss R. A. Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells. Nature. 1989 Jan 26;337(6205):368–370. doi: 10.1038/337368a0. [DOI] [PubMed] [Google Scholar]
  17. Cohen J. A., Laudenslager M. Autonomic nervous system involvement in patients with human immunodeficiency virus infection. Neurology. 1989 Aug;39(8):1111–1112. doi: 10.1212/wnl.39.8.1111. [DOI] [PubMed] [Google Scholar]
  18. Cornblath D. R., McArthur J. C., Kennedy P. G., Witte A. S., Griffin J. W. Inflammatory demyelinating peripheral neuropathies associated with human T-cell lymphotropic virus type III infection. Ann Neurol. 1987 Jan;21(1):32–40. doi: 10.1002/ana.410210107. [DOI] [PubMed] [Google Scholar]
  19. Cornblath D. R. Treatment of the neuromuscular complications of human immunodeficiency virus infection. Ann Neurol. 1988;23 (Suppl):S88–S91. doi: 10.1002/ana.410230723. [DOI] [PubMed] [Google Scholar]
  20. Currie J., Benson E., Ramsden B., Perdices M., Cooper D. Eye movement abnormalities as a predictor of the acquired immunodeficiency syndrome dementia complex. Arch Neurol. 1988 Sep;45(9):949–953. doi: 10.1001/archneur.1988.00520330027006. [DOI] [PubMed] [Google Scholar]
  21. Dalakas M. C., Pezeshkpour G. H., Gravell M., Sever J. L. Polymyositis associated with AIDS retrovirus. JAMA. 1986 Nov 7;256(17):2381–2383. [PubMed] [Google Scholar]
  22. Dawson V. L., Dawson T. M., Uhl G. R., Snyder S. H. Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3256–3259. doi: 10.1073/pnas.90.8.3256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Dewhurst S., Bresser J., Stevenson M., Sakai K., Evinger-Hodges M. J., Volsky D. J. Susceptibility of human glial cells to infection with human immunodeficiency virus (HIV). FEBS Lett. 1987 Mar 9;213(1):138–143. doi: 10.1016/0014-5793(87)81479-5. [DOI] [PubMed] [Google Scholar]
  24. Engstrom J. W., Lowenstein D. H., Bredesen D. E. Cerebral infarctions and transient neurologic deficits associated with acquired immunodeficiency syndrome. Am J Med. 1989 May;86(5):528–532. doi: 10.1016/0002-9343(89)90379-3. [DOI] [PubMed] [Google Scholar]
  25. Epstein L. G., Kuiken C., Blumberg B. M., Hartman S., Sharer L. R., Clement M., Goudsmit J. HIV-1 V3 domain variation in brain and spleen of children with AIDS: tissue-specific evolution within host-determined quasispecies. Virology. 1991 Feb;180(2):583–590. doi: 10.1016/0042-6822(91)90072-j. [DOI] [PubMed] [Google Scholar]
  26. Esiri M. M., Morris C. S., Millard P. R. Fate of oligodendrocytes in HIV-1 infection. AIDS. 1991 Sep;5(9):1081–1088. doi: 10.1097/00002030-199109000-00003. [DOI] [PubMed] [Google Scholar]
  27. Everall I. P., Luthert P. J., Lantos P. L. Neuronal loss in the frontal cortex in HIV infection. Lancet. 1991 May 11;337(8750):1119–1121. doi: 10.1016/0140-6736(91)92786-2. [DOI] [PubMed] [Google Scholar]
  28. Freeman R., Roberts M. S., Friedman L. S., Broadbridge C. Autonomic function and human immunodeficiency virus infection. Neurology. 1990 Apr;40(4):575–580. doi: 10.1212/wnl.40.4.575. [DOI] [PubMed] [Google Scholar]
  29. Fuchs D., Chiodi F., Albert J., Asjö B., Hagberg L., Hausen A., Norkrans G., Reibnegger G., Werner E. R., Wachter H. Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1. AIDS. 1989 May;3(5):285–288. doi: 10.1097/00002030-198905000-00006. [DOI] [PubMed] [Google Scholar]
  30. Fuller G. N., Jacobs J. M., Guiloff R. J. Association of painful peripheral neuropathy in AIDS with cytomegalovirus infection. Lancet. 1989 Oct 21;2(8669):937–941. doi: 10.1016/s0140-6736(89)90952-5. [DOI] [PubMed] [Google Scholar]
  31. Gabuzda D. H., Ho D. D., de la Monte S. M., Hirsch M. S., Rota T. R., Sobel R. A. Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS. Ann Neurol. 1986 Sep;20(3):289–295. doi: 10.1002/ana.410200304. [DOI] [PubMed] [Google Scholar]
  32. Gallo P., Frei K., Rordorf C., Lazdins J., Tavolato B., Fontana A. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. J Neuroimmunol. 1989 Jul;23(2):109–116. doi: 10.1016/0165-5728(89)90029-5. [DOI] [PubMed] [Google Scholar]
  33. Genis P., Jett M., Bernton E. W., Boyle T., Gelbard H. A., Dzenko K., Keane R. W., Resnick L., Mizrachi Y., Volsky D. J. Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J Exp Med. 1992 Dec 1;176(6):1703–1718. doi: 10.1084/jem.176.6.1703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Gessain A., Barin F., Vernant J. C., Gout O., Maurs L., Calender A., de Thé G. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985 Aug 24;2(8452):407–410. doi: 10.1016/s0140-6736(85)92734-5. [DOI] [PubMed] [Google Scholar]
  35. Gherardi R., Lebargy F., Gaulard P., Mhiri C., Bernaudin J. F., Gray F. Necrotizing vasculitis and HIV replication in peripheral nerves. N Engl J Med. 1989 Sep 7;321(10):685–686. doi: 10.1056/NEJM198909073211013. [DOI] [PubMed] [Google Scholar]
  36. Giulian D., Vaca K., Noonan C. A. Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science. 1990 Dec 14;250(4987):1593–1596. doi: 10.1126/science.2148832. [DOI] [PubMed] [Google Scholar]
  37. Goodin D. S., Aminoff M. J., Chernoff D. N., Hollander H. Long latency event-related potentials in patients infected with human immunodeficiency virus. Ann Neurol. 1990 Apr;27(4):414–419. doi: 10.1002/ana.410270409. [DOI] [PubMed] [Google Scholar]
  38. Goswami K. K., Miller R. F., Harrison M. J., Hamel D. J., Daniels R. S., Tedder R. S. Expression of HIV-1 in the cerebrospinal fluid detected by the polymerase chain reaction and its correlation with central nervous system disease. AIDS. 1991 Jul;5(7):797–803. doi: 10.1097/00002030-199107000-00002. [DOI] [PubMed] [Google Scholar]
  39. Grafe M. R., Wiley C. A. Spinal cord and peripheral nerve pathology in AIDS: the roles of cytomegalovirus and human immunodeficiency virus. Ann Neurol. 1989 Jun;25(6):561–566. doi: 10.1002/ana.410250606. [DOI] [PubMed] [Google Scholar]
  40. Grant I., Atkinson J. H., Hesselink J. R., Kennedy C. J., Richman D. D., Spector S. A., McCutchan J. A. Evidence for early central nervous system involvement in the acquired immunodeficiency syndrome (AIDS) and other human immunodeficiency virus (HIV) infections. Studies with neuropsychologic testing and magnetic resonance imaging. Ann Intern Med. 1987 Dec;107(6):828–836. doi: 10.7326/0003-4819-107-6-828. [DOI] [PubMed] [Google Scholar]
  41. Gray F., Lescs M. C., Keohane C., Paraire F., Marc B., Durigon M., Gherardi R. Early brain changes in HIV infection: neuropathological study of 11 HIV seropositive, non-AIDS cases. J Neuropathol Exp Neurol. 1992 Mar;51(2):177–185. doi: 10.1097/00005072-199203000-00007. [DOI] [PubMed] [Google Scholar]
  42. Grimaldi L. M., Martino G. V., Franciotta D. M., Brustia R., Castagna A., Pristerà R., Lazzarin A. Elevated alpha-tumor necrosis factor levels in spinal fluid from HIV-1-infected patients with central nervous system involvement. Ann Neurol. 1991 Jan;29(1):21–25. doi: 10.1002/ana.410290106. [DOI] [PubMed] [Google Scholar]
  43. Gyorkey F., Melnick J. L., Gyorkey P. Human immunodeficiency virus in brain biopsies of patients with AIDS and progressive encephalopathy. J Infect Dis. 1987 May;155(5):870–876. doi: 10.1093/infdis/155.5.870. [DOI] [PubMed] [Google Scholar]
  44. Haase A. T. Pathogenesis of lentivirus infections. Nature. 1986 Jul 10;322(6075):130–136. doi: 10.1038/322130a0. [DOI] [PubMed] [Google Scholar]
  45. Harouse J. M., Bhat S., Spitalnik S. L., Laughlin M., Stefano K., Silberberg D. H., Gonzalez-Scarano F. Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide. Science. 1991 Jul 19;253(5017):320–323. doi: 10.1126/science.1857969. [DOI] [PubMed] [Google Scholar]
  46. Harouse J. M., Wroblewska Z., Laughlin M. A., Hickey W. F., Schonwetter B. S., Gonzalez-Scarano F. Human choroid plexus cells can be latently infected with human immunodeficiency virus. Ann Neurol. 1989 Apr;25(4):406–411. doi: 10.1002/ana.410250414. [DOI] [PubMed] [Google Scholar]
  47. Harrington W. J., Jr, Sheremata W., Hjelle B., Dube D. K., Bradshaw P., Foung S. K., Snodgrass S., Toedter G., Cabral L., Poiesz B. Spastic ataxia associated with human T-cell lymphotropic virus type II infection. Ann Neurol. 1993 Apr;33(4):411–414. doi: 10.1002/ana.410330416. [DOI] [PubMed] [Google Scholar]
  48. Heyes M. P., Brew B. J., Martin A., Price R. W., Salazar A. M., Sidtis J. J., Yergey J. A., Mouradian M. M., Sadler A. E., Keilp J. Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann Neurol. 1991 Feb;29(2):202–209. doi: 10.1002/ana.410290215. [DOI] [PubMed] [Google Scholar]
  49. Hollander H. Cerebrospinal fluid normalities and abnormalities in individuals infected with human immunodeficiency virus. J Infect Dis. 1988 Oct;158(4):855–858. doi: 10.1093/infdis/158.4.855. [DOI] [PubMed] [Google Scholar]
  50. Holtzman D. M., Kaku D. A., So Y. T. New-onset seizures associated with human immunodeficiency virus infection: causation and clinical features in 100 cases. Am J Med. 1989 Aug;87(2):173–177. doi: 10.1016/s0002-9343(89)80693-x. [DOI] [PubMed] [Google Scholar]
  51. Human immunodeficiency virus in glial cells? J Infect Dis. 1988 Jan;157(1):203–205. doi: 10.1093/infdis/157.1.203. [DOI] [PubMed] [Google Scholar]
  52. International collaboration. Nature. 1990 Jan 4;343(6253):5–6. doi: 10.1038/343005c0. [DOI] [PubMed] [Google Scholar]
  53. Jacobson S., Lehky T., Nishimura M., Robinson S., McFarlin D. E., Dhib-Jalbut S. Isolation of HTLV-II from a patient with chronic, progressive neurological disease clinically indistinguishable from HTLV-I-associated myelopathy/tropical spastic paraparesis. Ann Neurol. 1993 Apr;33(4):392–396. doi: 10.1002/ana.410330411. [DOI] [PubMed] [Google Scholar]
  54. Janssen R. S., Saykin A. J., Cannon L., Campbell J., Pinsky P. F., Hessol N. A., O'Malley P. M., Lifson A. R., Doll L. S., Rutherford G. W. Neurological and neuropsychological manifestations of HIV-1 infection: association with AIDS-related complex but not asymptomatic HIV-1 infection. Ann Neurol. 1989 Nov;26(5):592–600. doi: 10.1002/ana.410260503. [DOI] [PubMed] [Google Scholar]
  55. Jarvik J. G., Hesselink J. R., Kennedy C., Teschke R., Wiley C., Spector S., Richman D., McCutchan J. A. Acquired immunodeficiency syndrome. Magnetic resonance patterns of brain involvement with pathologic correlation. Arch Neurol. 1988 Jul;45(7):731–736. doi: 10.1001/archneur.1988.00520310037014. [DOI] [PubMed] [Google Scholar]
  56. Kamin S. S., Petito C. K. Idiopathic myelopathies with white matter vacuolation in non-acquired immunodeficiency syndrome patients. Hum Pathol. 1991 Aug;22(8):816–824. doi: 10.1016/0046-8177(91)90211-7. [DOI] [PubMed] [Google Scholar]
  57. Keating J. N., Trimble K. C., Mulcahy F., Scott J. M., Weir D. G. Evidence of brain methyltransferase inhibition and early brain involvement in HIV-positive patients. Lancet. 1991 Apr 20;337(8747):935–939. doi: 10.1016/0140-6736(91)91570-k. [DOI] [PubMed] [Google Scholar]
  58. Ketzler S., Weis S., Haug H., Budka H. Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol. 1990;80(1):92–94. doi: 10.1007/BF00294228. [DOI] [PubMed] [Google Scholar]
  59. Koralnik I. J., Beaumanoir A., Häusler R., Kohler A., Safran A. B., Delacoux R., Vibert D., Mayer E., Burkhard P., Nahory A. A controlled study of early neurologic abnormalities in men with asymptomatic human immunodeficiency virus infection. N Engl J Med. 1990 Sep 27;323(13):864–870. doi: 10.1056/NEJM199009273231303. [DOI] [PubMed] [Google Scholar]
  60. Koyanagi Y., Miles S., Mitsuyasu R. T., Merrill J. E., Vinters H. V., Chen I. S. Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science. 1987 May 15;236(4803):819–822. doi: 10.1126/science.3646751. [DOI] [PubMed] [Google Scholar]
  61. Kure K., Lyman W. D., Weidenheim K. M., Dickson D. W. Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method. Am J Pathol. 1990 May;136(5):1085–1092. [PMC free article] [PubMed] [Google Scholar]
  62. Kure K., Weidenheim K. M., Lyman W. D., Dickson D. W. Morphology and distribution of HIV-1 gp41-positive microglia in subacute AIDS encephalitis. Pattern of involvement resembling a multisystem degeneration. Acta Neuropathol. 1990;80(4):393–400. doi: 10.1007/BF00307693. [DOI] [PubMed] [Google Scholar]
  63. Lassmann H., Zimprich F., Vass K., Hickey W. F. Microglial cells are a component of the perivascular glia limitans. J Neurosci Res. 1991 Feb;28(2):236–243. doi: 10.1002/jnr.490280211. [DOI] [PubMed] [Google Scholar]
  64. Layzer R. B. Myeloneuropathy after prolonged exposure to nitrous oxide. Lancet. 1978 Dec 9;2(8102):1227–1230. doi: 10.1016/s0140-6736(78)92101-3. [DOI] [PubMed] [Google Scholar]
  65. Li Y., Kappes J. C., Conway J. A., Price R. W., Shaw G. M., Hahn B. H. Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes. J Virol. 1991 Aug;65(8):3973–3985. doi: 10.1128/jvi.65.8.3973-3985.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Lipkin W. I., Parry G., Kiprov D., Abrams D. Inflammatory neuropathy in homosexual men with lymphadenopathy. Neurology. 1985 Oct;35(10):1479–1483. doi: 10.1212/wnl.35.10.1479. [DOI] [PubMed] [Google Scholar]
  67. Lipton S. A. Models of neuronal injury in AIDS: another role for the NMDA receptor? Trends Neurosci. 1992 Mar;15(3):75–79. doi: 10.1016/0166-2236(92)90013-x. [DOI] [PubMed] [Google Scholar]
  68. Lipton S. A. Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. Neuroreport. 1992 Oct;3(10):913–915. doi: 10.1097/00001756-199210000-00023. [DOI] [PubMed] [Google Scholar]
  69. Maclean C., Flegg P. J., Kilpatrick D. C. Anti-cardiolipin antibodies and HIV infection. Clin Exp Immunol. 1990 Aug;81(2):263–266. doi: 10.1111/j.1365-2249.1990.tb03328.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Mah V., Vartavarian L. M., Akers M. A., Vinters H. V. Abnormalities of peripheral nerve in patients with human immunodeficiency virus infection. Ann Neurol. 1988 Dec;24(6):713–717. doi: 10.1002/ana.410240604. [DOI] [PubMed] [Google Scholar]
  71. Maini C. L., Pigorini F., Pau F. M., Volpini V., Galgani S., Rosci M. A., Narciso P. Cortical cerebral blood flow in HIV-1-related dementia complex. Nucl Med Commun. 1990 Sep;11(9):639–648. doi: 10.1097/00006231-199009000-00007. [DOI] [PubMed] [Google Scholar]
  72. Marshall D. W., Brey R. L., Cahill W. T., Houk R. W., Zajac R. A., Boswell R. N. Spectrum of cerebrospinal fluid findings in various stages of human immunodeficiency virus infection. Arch Neurol. 1988 Sep;45(9):954–958. doi: 10.1001/archneur.1988.00520330032007. [DOI] [PubMed] [Google Scholar]
  73. Masdeu J. C., Yudd A., Van Heertum R. L., Grundman M., Hriso E., O'Connell R. A., Luck D., Camli U., King L. N. Single-photon emission computed tomography in human immunodeficiency virus encephalopathy: a preliminary report. J Nucl Med. 1991 Aug;32(8):1471–1475. [PubMed] [Google Scholar]
  74. Mastroianni C. M., Liuzzi G. M., Jirillo E., Vullo V., Delia S., Riccio P. Cerebrospinal fluid markers for the monitoring of AIDS dementia complex severity: usefulness of anti-myelin basic protein antibody detection. AIDS. 1991 Apr;5(4):464–465. doi: 10.1097/00002030-199104000-00023. [DOI] [PubMed] [Google Scholar]
  75. McArthur J. C., Cohen B. A., Farzedegan H., Cornblath D. R., Selnes O. A., Ostrow D., Johnson R. T., Phair J., Polk B. F. Cerebrospinal fluid abnormalities in homosexual men with and without neuropsychiatric findings. Ann Neurol. 1988;23 (Suppl):S34–S37. doi: 10.1002/ana.410230712. [DOI] [PubMed] [Google Scholar]
  76. McArthur J. C., Cohen B. A., Selnes O. A., Kumar A. J., Cooper K., McArthur J. H., Soucy G., Cornblath D. R., Chmiel J. S., Wang M. C. Low prevalence of neurological and neuropsychological abnormalities in otherwise healthy HIV-1-infected individuals: results from the multicenter AIDS Cohort Study. Ann Neurol. 1989 Nov;26(5):601–611. doi: 10.1002/ana.410260504. [DOI] [PubMed] [Google Scholar]
  77. McArthur J. C. Neurologic manifestations of AIDS. Medicine (Baltimore) 1987 Nov;66(6):407–437. doi: 10.1097/00005792-198711000-00001. [DOI] [PubMed] [Google Scholar]
  78. Merrill P. T., Paige G. D., Abrams R. A., Jacoby R. G., Clifford D. B. Ocular motor abnormalities in human immunodeficiency virus infection. Ann Neurol. 1991 Aug;30(2):130–138. doi: 10.1002/ana.410300203. [DOI] [PubMed] [Google Scholar]
  79. Meyerhoff D. J., MacKay S., Bachman L., Poole N., Dillon W. P., Weiner M. W., Fein G. Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus-seropositive individuals: in vivo 1H magnetic resonance spectroscopic imaging. Neurology. 1993 Mar;43(3 Pt 1):509–515. doi: 10.1212/wnl.43.3_part_1.509. [DOI] [PubMed] [Google Scholar]
  80. Michaels J., Price R. W., Rosenblum M. K. Microglia in the giant cell encephalitis of acquired immune deficiency syndrome: proliferation, infection and fusion. Acta Neuropathol. 1988;76(4):373–379. doi: 10.1007/BF00686974. [DOI] [PubMed] [Google Scholar]
  81. Miller E. N., Selnes O. A., McArthur J. C., Satz P., Becker J. T., Cohen B. A., Sheridan K., Machado A. M., Van Gorp W. G., Visscher B. Neuropsychological performance in HIV-1-infected homosexual men: The Multicenter AIDS Cohort Study (MACS) Neurology. 1990 Feb;40(2):197–203. doi: 10.1212/wnl.40.2.197. [DOI] [PubMed] [Google Scholar]
  82. Mizusawa H., Hirano A., Llena J. F., Shintaku M. Cerebrovascular lesions in acquired immune deficiency syndrome (AIDS). Acta Neuropathol. 1988;76(5):451–457. doi: 10.1007/BF00686383. [DOI] [PubMed] [Google Scholar]
  83. Navia B. A., Cho E. S., Petito C. K., Price R. W. The AIDS dementia complex: II. Neuropathology. Ann Neurol. 1986 Jun;19(6):525–535. doi: 10.1002/ana.410190603. [DOI] [PubMed] [Google Scholar]
  84. Navia B. A., Jordan B. D., Price R. W. The AIDS dementia complex: I. Clinical features. Ann Neurol. 1986 Jun;19(6):517–524. doi: 10.1002/ana.410190602. [DOI] [PubMed] [Google Scholar]
  85. Nuwer M. R., Miller E. N., Visscher B. R., Niedermeyer E., Packwood J. W., Carlson L. G., Satz P., Jankel W., McArthur J. C. Asymptomatic HIV infection does not cause EEG abnormalities: results from the Multicenter AIDS Cohort Study (MACS) Neurology. 1992 Jun;42(6):1214–1219. doi: 10.1212/wnl.42.6.1214. [DOI] [PubMed] [Google Scholar]
  86. Osame M., Usuku K., Izumo S., Ijichi N., Amitani H., Igata A., Matsumoto M., Tara M. HTLV-I associated myelopathy, a new clinical entity. Lancet. 1986 May 3;1(8488):1031–1032. doi: 10.1016/s0140-6736(86)91298-5. [DOI] [PubMed] [Google Scholar]
  87. Pagano M. A., Cahn P. E., Garau M. L., Mangone C. A., Figini H. A., Yorio A. A., Dellepiane M. C., Amores M. G., Perez H. M., Casiró A. D. Brain-stem auditory evoked potentials in human immunodeficiency virus-seropositive patients with and without acquired immunodeficiency syndrome. Arch Neurol. 1992 Feb;49(2):166–169. doi: 10.1001/archneur.1992.00530260068022. [DOI] [PubMed] [Google Scholar]
  88. Parisi A., Di Perri G., Strosselli M., Nappi G., Minoli L., Rondanelli E. G. Usefulness of computerized electroencephalography in diagnosing, staging and monitoring AIDS-dementia complex. AIDS. 1989 Apr;3(4):209–213. doi: 10.1097/00002030-198904000-00003. [DOI] [PubMed] [Google Scholar]
  89. Peluso R., Haase A., Stowring L., Edwards M., Ventura P. A Trojan Horse mechanism for the spread of visna virus in monocytes. Virology. 1985 Nov;147(1):231–236. doi: 10.1016/0042-6822(85)90246-6. [DOI] [PubMed] [Google Scholar]
  90. Petito C. K., Cash K. S. Blood-brain barrier abnormalities in the acquired immunodeficiency syndrome: immunohistochemical localization of serum proteins in postmortem brain. Ann Neurol. 1992 Nov;32(5):658–666. doi: 10.1002/ana.410320509. [DOI] [PubMed] [Google Scholar]
  91. Petito C. K., Navia B. A., Cho E. S., Jordan B. D., George D. C., Price R. W. Vacuolar myelopathy pathologically resembling subacute combined degeneration in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1985 Apr 4;312(14):874–879. doi: 10.1056/NEJM198504043121402. [DOI] [PubMed] [Google Scholar]
  92. Portegies P., Epstein L. G., Hung S. T., de Gans J., Goudsmit J. Human immunodeficiency virus type 1 antigen in cerebrospinal fluid. Correlation with clinical neurologic status. Arch Neurol. 1989 Mar;46(3):261–264. doi: 10.1001/archneur.1989.00520390027010. [DOI] [PubMed] [Google Scholar]
  93. Portegies P., de Gans J., Lange J. M., Derix M. M., Speelman H., Bakker M., Danner S. A., Goudsmit J. Declining incidence of AIDS dementia complex after introduction of zidovudine treatment. BMJ. 1989 Sep 30;299(6703):819–821. doi: 10.1136/bmj.299.6703.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Resnick L., Berger J. R., Shapshak P., Tourtellotte W. W. Early penetration of the blood-brain-barrier by HIV. Neurology. 1988 Jan;38(1):9–14. doi: 10.1212/wnl.38.1.9. [DOI] [PubMed] [Google Scholar]
  95. Rosenblum M., Scheck A. C., Cronin K., Brew B. J., Khan A., Paul M., Price R. W. Dissociation of AIDS-related vacuolar myelopathy and productive HIV-1 infection of the spinal cord. Neurology. 1989 Jul;39(7):892–896. doi: 10.1212/wnl.39.7.892. [DOI] [PubMed] [Google Scholar]
  96. Rottenberg D. A., Moeller J. R., Strother S. C., Sidtis J. J., Navia B. A., Dhawan V., Ginos J. Z., Price R. W. The metabolic pathology of the AIDS dementia complex. Ann Neurol. 1987 Dec;22(6):700–706. doi: 10.1002/ana.410220605. [DOI] [PubMed] [Google Scholar]
  97. Said G., Lacroix C., Chemouilli P., Goulon-Goeau C., Roullet E., Penaud D., de Broucker T., Meduri G., Vincent D., Torchet M. Cytomegalovirus neuropathy in acquired immunodeficiency syndrome: a clinical and pathological study. Ann Neurol. 1991 Feb;29(2):139–146. doi: 10.1002/ana.410290205. [DOI] [PubMed] [Google Scholar]
  98. Schielke E., Tatsch K., Pfister H. W., Trenkwalder C., Leinsinger G., Kirsch C. M., Matuschke A., Einhäupl K. M. Reduced cerebral blood flow in early stages of human immunodeficiency virus infection. Arch Neurol. 1990 Dec;47(12):1342–1345. doi: 10.1001/archneur.1990.00530120088015. [DOI] [PubMed] [Google Scholar]
  99. Schmitt F. A., Bigley J. W., McKinnis R., Logue P. E., Evans R. W., Drucker J. L. Neuropsychological outcome of zidovudine (AZT) treatment of patients with AIDS and AIDS-related complex. N Engl J Med. 1988 Dec 15;319(24):1573–1578. doi: 10.1056/NEJM198812153192404. [DOI] [PubMed] [Google Scholar]
  100. Shapshak P., Yoshioka M., Sun N. C., Nelson S. J., Rhodes R. H., Schiller P., Resnick L., Shah S. M., Svenningsson A., Imagawa D. T. HIV-1 in postmortem brain tissue from patients with AIDS: a comparison of different detection techniques. AIDS. 1992 Sep;6(9):915–923. doi: 10.1097/00002030-199209000-00002. [DOI] [PubMed] [Google Scholar]
  101. Sharer L. R., Dowling P. C., Michaels J., Cook S. D., Menonna J., Blumberg B. M., Epstein L. G. Spinal cord disease in children with HIV-1 infection: a combined molecular biological and neuropathological study. Neuropathol Appl Neurobiol. 1990 Aug;16(4):317–331. doi: 10.1111/j.1365-2990.1990.tb01266.x. [DOI] [PubMed] [Google Scholar]
  102. Shaunak S., Albright R. E., Klotman M. E., Henry S. C., Bartlett J. A., Hamilton J. D. Amplification of HIV-1 provirus from cerebrospinal fluid and its correlation with neurologic disease. J Infect Dis. 1990 Jun;161(6):1068–1072. doi: 10.1093/infdis/161.6.1068. [DOI] [PubMed] [Google Scholar]
  103. Sidtis J. J., Gatsonis C., Price R. W., Singer E. J., Collier A. C., Richman D. D., Hirsch M. S., Schaerf F. W., Fischl M. A., Kieburtz K. Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial. AIDS Clinical Trials Group. Ann Neurol. 1993 Apr;33(4):343–349. doi: 10.1002/ana.410330403. [DOI] [PubMed] [Google Scholar]
  104. Simpson D. M., Bender A. N. Human immunodeficiency virus-associated myopathy: analysis of 11 patients. Ann Neurol. 1988 Jul;24(1):79–84. doi: 10.1002/ana.410240114. [DOI] [PubMed] [Google Scholar]
  105. Simpson D. M., Wolfe D. E. Neuromuscular complications of HIV infection and its treatment. AIDS. 1991 Aug;5(8):917–926. doi: 10.1097/00002030-199108000-00001. [DOI] [PubMed] [Google Scholar]
  106. So Y. T., Holtzman D. M., Abrams D. I., Olney R. K. Peripheral neuropathy associated with acquired immunodeficiency syndrome. Prevalence and clinical features from a population-based survey. Arch Neurol. 1988 Sep;45(9):945–948. doi: 10.1001/archneur.1988.00520330023005. [DOI] [PubMed] [Google Scholar]
  107. Stoler M. H., Eskin T. A., Benn S., Angerer R. C., Angerer L. M. Human T-cell lymphotropic virus type III infection of the central nervous system. A preliminary in situ analysis. JAMA. 1986 Nov 7;256(17):2360–2364. [PubMed] [Google Scholar]
  108. Surtees R., Hyland K., Smith I. Central-nervous-system methyl-group metabolism in children with neurological complications of HIV infection. Lancet. 1990 Mar 17;335(8690):619–621. doi: 10.1016/0140-6736(90)90409-x. [DOI] [PubMed] [Google Scholar]
  109. Sönnerborg A. B., von Stedingk L. V., Hansson L. O., Strannegård O. O. Elevated neopterin and beta 2-microglobulin levels in blood and cerebrospinal fluid occur early in HIV-1 infection. AIDS. 1989 May;3(5):277–283. doi: 10.1097/00002030-198905000-00005. [DOI] [PubMed] [Google Scholar]
  110. Tyor W. R., Glass J. D., Griffin J. W., Becker P. S., McArthur J. C., Bezman L., Griffin D. E. Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann Neurol. 1992 Apr;31(4):349–360. doi: 10.1002/ana.410310402. [DOI] [PubMed] [Google Scholar]
  111. Vago L., Castagna A., Lazzarin A., Trabattoni G., Cinque P., Costanzi G. Reduced frequency of HIV-induced brain lesions in AIDS patients treated with zidovudine. J Acquir Immune Defic Syndr. 1993 Jan;6(1):42–45. [PubMed] [Google Scholar]
  112. Vazeux R., Lacroix-Ciaudo C., Blanche S., Cumont M. C., Henin D., Gray F., Boccon-Gibod L., Tardieu M. Low levels of human immunodeficiency virus replication in the brain tissue of children with severe acquired immunodeficiency syndrome encephalopathy. Am J Pathol. 1992 Jan;140(1):137–144. [PMC free article] [PubMed] [Google Scholar]
  113. Watkins B. A., Dorn H. H., Kelly W. B., Armstrong R. C., Potts B. J., Michaels F., Kufta C. V., Dubois-Dalcq M. Specific tropism of HIV-1 for microglial cells in primary human brain cultures. Science. 1990 Aug 3;249(4968):549–553. doi: 10.1126/science.2200125. [DOI] [PubMed] [Google Scholar]
  114. Weiser B., Peress N., La Neve D., Eilbott D. J., Seidman R., Burger H. Human immunodeficiency virus type 1 expression in the central nervous system correlates directly with extent of disease. Proc Natl Acad Sci U S A. 1990 May;87(10):3997–4001. doi: 10.1073/pnas.87.10.3997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  115. Wiley C. A., Masliah E., Morey M., Lemere C., DeTeresa R., Grafe M., Hansen L., Terry R. Neocortical damage during HIV infection. Ann Neurol. 1991 Jun;29(6):651–657. doi: 10.1002/ana.410290613. [DOI] [PubMed] [Google Scholar]
  116. Wilkie F. L., Eisdorfer C., Morgan R., Loewenstein D. A., Szapocznik J. Cognition in early human immunodeficiency virus infection. Arch Neurol. 1990 Apr;47(4):433–440. doi: 10.1001/archneur.1990.00530040085022. [DOI] [PubMed] [Google Scholar]
  117. Wong M. C., Suite N. D., Labar D. R. Seizures in human immunodeficiency virus infection. Arch Neurol. 1990 Jun;47(6):640–642. doi: 10.1001/archneur.1990.00530060048015. [DOI] [PubMed] [Google Scholar]
  118. Yankner B. A., Skolnik P. R., Shoukimas G. M., Gabuzda D. H., Sobel R. A., Ho D. D. Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system. Ann Neurol. 1986 Sep;20(3):362–364. doi: 10.1002/ana.410200316. [DOI] [PubMed] [Google Scholar]
  119. de la Monte S. M., Gabuzda D. H., Ho D. D., Brown R. H., Jr, Hedley-Whyte E. T., Schooley R. T., Hirsch M. S., Bhan A. K. Peripheral neuropathy in the acquired immunodeficiency syndrome. Ann Neurol. 1988 May;23(5):485–492. doi: 10.1002/ana.410230510. [DOI] [PubMed] [Google Scholar]

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