Table 2.
Paired comparison of data at baseline and at last follow up, according to the type of genetic alteration
| Organ | ALL | Missense mutation | Truncation mutation | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| baseline | Last FU | P-value | baseline | Last FU | P-value | baseline | Last FU | P-value | |||||||
| No | Yes | total | No | Yes | total | No | Yes | total | |||||||
|
Hemangioblastoma, brain Renal cell carcinoma |
+ | 8 (10.13) | 44 (55.7) | 52 (65.82) |
.132 .090 |
+ | 6 (8.45) | 40 (56.34) | 46 (64.79) |
.317 .013 |
+ | 2 (25) | 4 (50) | 6 (75) |
.157 .317 |
| total | 32 (40.51) | 47 (59.49) | 79 (100) | total | 28 (39.44) | 43 (60.56) | 71 (100) | total | 4 (50) | 4 (50) | 8 (100) | ||||
| + | 12 (14.63) | 15 (18.29) | 27 (32.93) | + | 11 (15.07) | 14 (19.18) | 25 (34.25) | + | 1 (11.11) | 1 (11.11) | 2 (22.22) | ||||
| Hemangioblastoma, spine | total | 62 (75.61) | 20 (24.39) | 82 (100) | .739 | total | 57 (78.08) | 16 (21.92) | 73 (100) | .739 | total | 5 (55.56) | 4 (44.44) | 9 (100) | > .999 |
| + | 5 (8.62) | 31 (53.45) | 36 (62.07) | + | 5 (9.09) | 29 (52.73) | 34 (61.82) | + | 0 (0) | 2 (66.67) | 2 (66.67) | ||||
| total | 23 (39.66) | 35 (60.34) | 58 (100) | total | 22 (40) | 33 (60) | 55 (100) | total | 1 (33.33) | 2 (66.67) | 3 (100) | ||||
|
Renal cysts (Kidney cysts) Adrenal, |
+ | 1 (1.24) | 42 (52.5) | 43 (53.75) |
.180 < .001 |
+ | 1 (1.39) | 36 (50) | 37 (51.39) |
.180 < .001 |
+ | 0 (0) | 6 (75) | 6 (75) |
> .999 .317 |
| total | 34 (42.5) | 46 (57.5) | 80 (100) | total | 32 (44.44) | 40 (55.56) | 72 (100) | total | 2(25) | 6 (75) | 8 (100) | ||||
| + | 21 (25.61) | 4 (4.88) | 25 (30.49) | + | 20 (27.03) | 2 (2.7) | 22 (29.73) | + | 1 (12.5) | 2 (25) | 3 (37.5) | ||||
|
Pheochromocytoma Pancreas, serous cystadenoma |
total | 76 (92.68) | 6 (7.32) | 82 (100) | .317 | total | 70 (94.59) | 4 (5.41) | 74 (100) | .564 | total | 6 (75) | 2 (25) | 8 (100) | .317 |
| + | 3 (3.7) | 24 (29.63) | 27 (33.33) | + | 2 (2.74) | 20 (27.4) | 22 (30.14) | + | 1 (12.5) | 4 (50) | 5 (62.5) | ||||
| total | 56 (69.14) | 25 (30.86)) | 81 (100) | total | 52 (71.23) | 21 (28.77) | 73 (100) | total | 4 (50) | 4 (50) | 8 (100) | ||||
| Pancreas, NET | + | 7 (8.54) | 8 (9.76) | 15 (18.29) | .366 | + | 6 (8.11) | 7 (9.46) | 13 (17.57) | .317 | + | 1 (12.5) | 1 (12.5) | 2 (25) | > .999 |
| total | 70 (85.37) | 12 (14.63) | 82 (100) | total | 64 (86.49( | 10 (13.51) | 74 (100) | total | 6 (75) | 2 (25) | 8 (100) | ||||