Table 3.

Cox proportional hazard regression based on the type of genetic alteration, clinical variables, and tumor volume

	Univariable Analysis		Multivariable Analysis
Variable	Hazard Ratio	P value	Hazard Ratio	P value
Hemangioblastoma, brain (n = 72)
Genetic mutation groups	1.627 (0.475, 5.573)	.438	0.801 (0.206, 3.120)	.750
Age	1.001 (0.978, 1.024)	.952	0.999 (0.974, 1.024)	.922
Sex (male vs. female)	0.822 (0.400, 1.692)	.595	0.923 (0.423, 2.015)	.840
Initial volume	1.028 (1.013, 1.044)	< .001	1.029 (1.013, 1.046)	< .001
Renal cell carcinoma (n = 82)
Genetic mutation groups	2.408 (0.811, 7.150)	.114	2.387 (0.771, 7.388)	.131
Age	0.980 (0.953, 1.007)	.145	0.978 (0.946, 1.011)	.191
Sex (male vs. female)	3.965 (1.651, 9.522)	.002	3.368 (1.351, 8.396)	.009
Initial volume	1.011 (1.005, 1.017)	< .001	1.011 (1.005, 1.017)	< .001

Genetic subtype groups are comparison between truncation mutation and missense mutation groups (reference: missense mutation)