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. 2025 Mar 28;15:10735. doi: 10.1038/s41598-025-94622-w

Table 2.

Mediation analysis between mVOCs and sarcopenia.

Result mVOCs Mediator Indirect effect
(P-value)
Direct effect
(P-value)
Total effect
(P-value)
Mediation proportions
Sarcopenia 3,4MHA White blood cell 0.000199(0.38) 0.013188(< 0.001) 0.013386(< 0.001) NA
Alkaline phosphatase − 0.000105(0.48) 0.013500(< 0.001) 0.013395(< 0.001) NA
Bilirubin − 0.00079(0.06) 0.014596(< 0.001) 0.013806(< 0.001) NA
Gamma glutamyl transferase − 0.000252(0.18) 0.013866(< 0.001) 0.013614(< 0.001) NA
ATCA White blood cell 0.001075(0.02) 0.013077(0.04) 0.014151(0.04) 7.6%
Alkaline phosphatase − 0.000294(0.24) 0.014431(0.02) 0.014137(0.02) NA
Bilirubin 0.001514(0.04) 0.012577(0.02) 0.014091(0.02) 10.7%
Gamma glutamyl transferase 1.64e−05(0.96) 1.46e-02(0.02) 0.0147(0.02) NA
DHBMA White blood cell 0.001981(0.02) 0.029344(< 0.001) 0.031325(< 0.001) 6.3%
Alkaline phosphatase 0.001048(0.34) 0.031559(< 0.001) 0.032607(< 0.001) NA
Bilirubin 0.003893(0.04) 0.027924(< 0.001) 0.031817(< 0.001) 12.2%
Gamma glutamyl transferase 0.000537(0.24) 0.031365(< 0.001) 0.031902(< 0.001) NA
3HPMA White blood cell 0.001914(0.04) 0.011726(0.02) 0.01364(0.02) 14%
Alkaline phosphatase 4.06e−04(0.12) 0.0135(0.02) 0.0139(0.02) NA
Bilirubin 0.00216(0.04) 0.01228(0.04) 0.01444(0.02) 15%
Gamma glutamyl transferase − 0.000114(0.72) 0.01363(0.02) 0.013516(0.02) NA

Bold indicates significant mediating relationships.