TABLE 1.

Antibiotic susceptibilities and β-lactamases characterized for oral Capnocytophaga isolates^a

Isolate	Identity (16S rRNA)	Source	Country of origin	Etest MIC (μg/ml) ofa:										β-Lactamase identity
				AC	XL	CT	FX	XM	EM	TC	CM	TZ	TZ- TZL
372	C. granulosa	Periodontitis	France	2	0.032	32	0.38	32	32	0.094	256	1.2	<0.064	CfxA3e
45	C. sputigena	NUGb	France	>256	0.19	2	0.75	>256	0.125	>256	0.016	2	<0.064	CfxA3
62	C. sputigena	Periodontitis	France	64	0.125	4	1	32	>256	1.5	>256	1	<0.064	CfxA2e
176	C. sputigena	Dental abscess	France	2	0.25	16	0.75	12	256	1.5	>256	4	0.01	CfxA3
315	C. sputigena	Periodontitis	France	>256	0.25	8	1	64	0.5	0.5	<0.016	32	<0.064	NDc
456	C. sputigena	Periodontitis	France	24	0.064	64	0.38	>256	0.125	0.125	<0.016	0.5	<0.064	ND
507	C. sputigena	Periodontitis	France	32	0.125	4	1	64	>256	0.38	>256	256	<0.064	ND
516	C. sputigena	Periodontitis	France	32	0.125	32	1	>256	>256	0.38	>256	24	<0.064	ND
581	C. sputigena	Periodontitis	France	64	0.047	2	0.38	12	0.19	0.064	<0.016	2	<0.064	ND
568	C. sputigena	Periodontitis	France	>256	0.25	4	0.75	32	>256	0.19	256	3	0.03	CfxA3
301d	C. sputigena	Periodontal lesion	U.S.	0.19	0.19	0.125	0.5	0.25	0.125	0.19	0.016	1.5	<0.064	—f
528	C. ochracea	Periodontitis	France	>256	0.75	256	2	128	0.125	0.125	0.023	256	<0.064	CfxA3
321d	C. ochracea	Blood	France	>256	0.5	256	1	>256	1.5	0.25	0.064	>256	<0.064	CfxA3
595	C. ochracea	Periodontitis	France	>256	0.125	64	1	256	256	0.38	>256	256	<0.064	CfxA3
616	C. ochracea	Periodontitis	France	>256	0.125	>256	1	>256	0.064	0.19	0.064	64	<0.064	CfxA3
800	C. ochracea	Periodontitis	France	>256	8	>256	2	>256	>256	0.38	>256	>256	<0.064	CfxA3
136	C. ochracea	Periodontitis	Norway	2	0.047	0.19	0.50	6	0.125	0.125	<0.016	0.125	<0.064	CfxA2
161	C. ochracea	Periodontitis	Norway	2	0.19	0.25	0.25	2	0.125	0.38	<0.016	0.047	<0.064	CfxA2
448d	C. ochracea	Oral cavity	U.S.	0.25	0.19	0.19	0.38	0.5	0.25	0.125	0.016	1.5	<0.064	—
140	C. gingivalis	Dental abscess	France	>256	1	256	1	>256	0.125	0.25	0.023	32	<0.064	CfxA3
8-01	C. gingivalis	Periodontitis	U.S.	2	0.064	3	2	32	0.75	0.25	<0.016	1.5	<0.064	CfxA3
11-01	C. gingivalis	Periodontitis	U.S.	256	0.75	256	0.5	256	0.125	0.25	<0.016	>256	<0.064	CfxA3
2-02	C. gingivalis	Periodontitis	U.S.	4	0.094	8	0.75	256	0.38	0.125	<0.016	4	<0.064	CfxA2
10-02A	C. gingivalis	Periodontitis	U.S.	1	0.032	6	0.25	24	0.047	1.5	<0.016	4	<0.064	CfxA2
10-02B	C. gingivalis	Periodontitis	U.S.	0.50	0.064	1	0.75	3	0.094	1	<0.016	1.5	<0.064	CfxA2
149	C. gingivalis	Periodontitis	Norway	32	0.032	256	0.75	256	0.125	0.125	<0.016	8	<0.064	CfxA2
7-02	Capnocytophaga sp.	Periodontitis	U.S.	2	0.064	0.125	0.125	0.75	0.094	0.125	<0.016	0.064	<0.064	CfxA2

^aAC, amoxicillin; XL, amoxicillin-clavulanic acid; CT, cefotaxime; FX, cefoxitin; XM, cefuroxime; EM, erythromycin; TC, tetracycline; CM, clindamycin; TZ, ceftazidime; TZ-TZL, ceftazidime-ceftazidime-clavulanic acid.

^bNUG, necrotizing ulcerative gingivitis.

^cND, not detected in PCR experiments with the CfxA primer.

^dReference strains: 301, C. sputigena ATCC 33612^T; 321, C. ochracea CIP 105321; 448, C. ochracea ATCC 27872^T.

^eAmino acids substitutions: from CfxA (Bacteroides vulgatus) to CfxA2, E72K; from CfxA to CfxA3, E72K and D239Y (16, 19).

^f—, β-lactamase negative.