FIG. 3.

BAL cytokine and chemokine concentrations in mice infected with M. pneumoniae (Mp) and treated with azithromycin (AZM) (10 mg/kg/day for 5 days or 50 mg/kg for 1 day) or placebo. Data are expressed as means or medians as described in the text. Error bars represent standard deviations when variables had a normal distribution and 25th to 75th percentiles when variables did not have a normal distribution. *, P < 0.05 (compared with placebo); 5 to 10 mice per treatment regimen at each time point. Values are results from two independent experiments. Of note, cytokines and chemokines were measured at day 4 of infection, when the daily treatment group had received a total of only 30 mg/kg of azithromycin while the single-high-dose group had received 50 mg/kg.