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Gender effects on pharmacokinetics of linezolid
| Parameter | Median value (interquartile range)
|
P value | |
|---|---|---|---|
| Males (n = 7) | Females (n = 10) | ||
| Ka (h−1) | 0.750 (0.250-6.25) | 0.895 (0.75-25.7) | 0.23 |
| F | 0.774 (0.618-0.878) | 0.923 (0.865-1.04) | 0.02 |
| K20 (h−1) | 0.605 (0.315-0.685) | 0.272 (0.205-0.415) | 0.04 |
| Vc (liters/kg) | 0.267 (0.195-0.330) | 0.370 (0.298-0.499) | 0.01 |
| K23 (h−1) | 2.33 (1.53-4.98) | 0.711 (0.3-1.55) | 0.01 |
| K32 (h−1) | 2.27 (2.12-4.87) | 3.70 (0.791-5.05) | 0.47 |
