Distribution of the ITC MICs, tested at 35°C, against the yeast (A) and the mycelial (B) phases of S. schenckii from patients with cutaneous and disseminated sporotrichosis. Geometric means for panel A, disseminated, 2.13 μg/ml; cutaneous, 0.63 μg/ml (P = 0.035, independent samples t test); geometric means for panel B, disseminated, 2.26 μg/ml; cutaneous, 1 μg/ml (P = 0.402, Mann-Whitney U test). P values refer to differences between the MICs for isolates from disseminated and cutaneous cases. Statistical significance was assessed at a P value of <0.05.