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. 2025 Feb 3;64(3):373–385. doi: 10.1007/s40262-025-01473-9

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 4 — Conservative SR with experimental FaSSIF data and SR with experimental FaSSIF data plus literature FaSSIF data. The shadow grey area represents the SR. Grey dotted lines represent the limits for FE categorization, green filled circles represent the compounds with FE positive and FaSSIF measured experimentally, green filled triangles represent the compounds with FE positive and FaSSIF from literature, orange filled circles represent the compounds with no FE and FaSSIF measured experimentally, orange filled triangles represent the compounds with no FE and FaSSIF from literature, non-filled circles present the compounds with FE positive (green) and no FE (orange) within conservative SR and SR with FaSSIF measured experimentally and selected for PBPK simulations of SLA. D dose, FaSSIF fasted state simulated intestinal fluid, FaSSIF/D dose-adjusted FaSSIF solubility, SR sensitivity range