A methodology has been proposed for the in silico prediction of positive food effect based on determining a sensitivity range of dose-adjusted fasted state simulated intestinal fluid solubility for BCS II/IV compounds.

Dose-adjusted fasted state simulated intestinal fluid solubility can be used to distinguish drugs with food effect from those with no food effect outside the sensitivity range.

Within the sensitivity range, where dose-adjusted fasted state simulated intestinal fluid solubility cannot discriminate drugs based on food effect, solubility-limited absorption can serve as a good surrogate for binary prediction of food effect.