Table 2.

Genome-wide significant loci in the multi-ancestry meta-analysis of dry eye disease (DED).

rsID	Chr:Pos	Nearest Gene	EA/NEA	EAF	N case	N	OR [L95, U95]	P-value	Effect Direction	I 2	Het. P-value
rs4682749	3:44,697,023	ZNF502	G/C	0.39	132,637	484,838	0.97 [0.96, 0.98]	9.95 × 10−9	−−−+	28.1	0.24
rs13107325	4:102,267,552	SLC39A8	T/C	0.08	131,118	479,545	1.07 [1.04, 1.09]	1.24 × 10−10	+++?	0.0	0.90
rs2411044	5:107,737,792	EFNA5	A/G	0.17	132,637	484,838	0.96 [0.95, 0.98]	2.77 × 10−8	−−−−	0.0	0.68
rs7731539	5:153,732,101	GRIA1	G/C	0.48	132,637	484,838	0.97 [0.96, 0.98]	2.84 × 10−8	−−−−	22.0	0.28
rs34025038	5:153,801,313	GRIA1	T/C	0.12	132,637	484,838	1.05 [1.03, 1.06]	9.81 × 10−9	++++	0.0	0.75
rs191549504	6:33,443,896	SYNGAP1	C/T	0.01	88,963	350,965	1.16 [1.11, 1.21]	4.18 × 10−10	+??−	0.0	0.50
rs2618471	8:11,501,511	BLK	G/C	0.35	132,637	484,838	1.03 [1.02, 1.04]	2.91 × 10−8	+++−	0.0	0.45
rs12779865	10:21,540,233	MLLT10	C/T	0.31	132,637	484,838	1.04 [1.03, 1.05]	1.58 × 10−13	+++−	35.2	0.20
rs77465292	11:47,586,360	FAM180B	C/T	0.13	132,637	484,838	0.96 [0.94, 0.97]	6.30 × 10−9	−−−+	65.8	0.03
rs2872878	19:19,369,712	GATAD2A	C/G	0.59	132,637	484,838	0.97 [0.96, 0.98]	4.77 × 10−9	−−−−	0.0	0.65

We identified 10 independent loci within 9 susceptibility regions, all of which were novel with respect to DED. Genomic coordinates correspond to the GRCh38 assembly. Ancestry-stratified summary statistics for each locus are provided in Table S6. Chr: chromosome; Pos: position; EA: effect allele; NEA: non-effect allele; EAF: effect allele frequency; N: sample size; OR [L95, U95]: odds ratio with lower and upper bounds of the 95% confidence interval; Effect Direction: SNP effect direction in the EUR, AFR, AMR, and EAS cohorts, respectively (“?” indicates the variant did not meet the allele frequency cutoff of 0.1% in that ancestry and was not included in the meta-analysis); I²: percentage of variation due to heterogeneity; Het. P-value: p-value of the Cochran’s Q heterogeneity test.