Table 1.
Demographics information of participants for identification of biomarkers.
| Discovery | Replication | |||
|---|---|---|---|---|
| Clinical status | CO | AD | CO | AD |
| Sample size, n | 1381 | 750 | 715 | 520 |
| Age | ||||
| mean ± SD | 72.4 ± 10.5 | 78.1 ± 8.7 | 72.5 ± 9.5 | 76.5 ± 9.4 |
| Range (min, max) | (27, 101) | (33, 104) | (33, 101) | (42, 98) |
| Sex | ||||
| Female | 54.31% | 59.22% | 42.86% | 54.55% |
| Male | 45.69% | 40.78% | 57.14% | 45.45% |
| APOE genotype | ||||
| APOE ε4+ | 33.1% | 57.9% | 25.5% | 56.5% |
| NA | 6 | 5 | 54 | 14 |
| Amyloid positivity | ||||
| A+ | 632 | 110 | 143 | 88 |
| A− | 271 | 264 | 48 | 93 |
| NA | 478 | 376 | 524 | 339 |
This table summarizes basic demographic information of study participants for identification of plasma proteomic biomarkers.
Abbreviations: CO: cognitively normal; AD: Alzheimer's disease; SD, standard deviation.