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. 2025 Feb 11;135(7):e186416. doi: 10.1172/JCI186416

Figure 2. Cardiac conduction intervals were rescued by overexpression of MBNL1 and/or MBNL2.

Figure 2

(A) QRS (left) and QTc (right) intervals were determined by surface ECG recordings in anesthetized CUG960 mice in response to dox induction with different treatments. On/off dox (+/–) animals were taken off dox at the time of AAV9 delivery and served as a control for complete recovery. Data on QRS and QTc intervals from MHCrtTA +dox control animals at 8 weeks of age are indicated by a dashed line (28). n ≥13 per cohort. Data represent the mean ± SEM and were analyzed using 2-way ANOVA followed by Tukey’s multiple-comparison test. (B) Percent rescue of QRS (left) and QTc (right) intervals was calculated using the average ECG parameters from the last time point (21 weeks of age). n ≥13 per cohort. Black lines represent the significant differences of corresponding groups compared with +dox or tdTomato controls; brown lines represent the significant differences between the corresponding groups and +/–dox and –dox controls. Data represent the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001, by 1-way ANOVA followed by Tukey’s multiple-comparison test.