Figure 3. Heart weight and echocardiographic parameters induced by CUG_exp RNA show significant or trending rescue with MBNL1 and/or MBNL2 overexpression.

(A) Heart weight was normalized to tibia length. (B and C) Left ventricle anterior wall (LVAW) thickness, (D and E) left ventricle internal diameter (LVID), (F and G) LV volume, (H) ejection fraction (EF), and (I) fractional shortening (FS) were determined by M-mode Echo. n ≥13 per cohort. All animals were analyzed at the 21-week time point. Data represent the mean ± SEM and were analyzed by ordinary 1-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. d, end of diastole; s, end of systole.