TABLE 4.

Reactivities obtained using different methods to detect antibodies to B. burgdorferi in Lyme borreliosis in patients from the United States

Test	% Reactivity (reference[s]) in patients with:
	EM, acute phase	EM, convalescent phasea	Neurological involvement	Arthritis
Whole-cell ELISA	33-49 (7, 8, 89, 337)	76-86 (7, 8, 89, 337)	79 (IgG ELISA) (84)	100 (IgG ELISA) (84)
IgM IBb	43-44 (7, 89)	75-84 (7, 89)	80c (84)	16c (84)
IgG IBb	0-13 (7), 43.6d	15-21 (7), 80d	64-72 (84)	96-100 (84)
Two-tier testing	29-40 (7, 15, 89, 227, 337)	29-78 (7, 15, 89, 227, 337)	87 (15)	97 (15)

^aSera obtained after antimicrobial treatment.

^bIgM and IgG IB criteria are those of Engstrom et al. (89) and Dressler et al. (84), respectively, except as indicated.

^cIgM IB criteria of Dressler et al. (84).

^dIgG IB criteria of Engstrom et al. (89).