TABLE 2.
Average Ks and Ka among closely related sequences at each HVR motif
| Groupa | Sequencesb | Ksc | Kac |
|---|---|---|---|
| HVR1 | |||
| a | 1;2 | 0 | 0 |
| b | 3;4;5;6 | 0 | 0.0233 |
| c | 7;8 | 0 | 0.0221 |
| d | 12;13 | 0 | 0 |
| e | 18;19;20;21;22;23 | 0 | 0.0573 |
| f | 24;25 | 0 | 0.0234 |
| g | 28;29;30 | 0 | 0.0268 |
| h | 32;33;34 | 0.0386 | 0.0519 |
| HVR2 | |||
| a | 1;2 | 0 | 0 |
| b | 3;4;5 | 0 | 0 |
| c | 6;9 | 0 | 0.0374 |
| d | 7;8 | 0 | 0.0183 |
| e | 11;17 | 0 | 0 |
| f | 13;18;19;21;22 | 0 | 0.0314 |
| g | 28;29 | 0 | 0.0186 |
| h | 33;34 | 0 | 0 |
| i | 39;40 | 0 | 0 |
| HVR3 | |||
| a | 1;2 | 0 | 0 |
| b | 3,4;34 | 0 | 0 |
| c* | 5;6;7;9;10 | 0.0316 | 0.0077 |
| d | 11;17;23 | 0 | 0.0131 |
| e | 18;22,24 | 0 | 0.0131 |
| f | 39;40 | 0 | 0.0381 |
| HVR4 | |||
| a | 2;14 | 0 | 0.0176 |
| b | 3;16;31 | 0 | 0.0500 |
| c | 4;8;26;34 | 0 | 0.0227 |
| d | 6;7;21 | 0 | 0 |
| e | 10;33 | 0 | 0 |
| f | 11;17;23;27 | 0 | 0.0220 |
| g | 12;19 | 0 | 0.0300 |
| h | 18;25 | 0 | 0.0362 |
a
Groups were extrapolated from phylogenies of HVR+s in Fig. 4. Only very closely related groups of sequences, i.e., showing Ks and Ka of <0.06, were considered. All groups but one (indicated with an asterisk), show Ks ≤ Ka.
b
Numbers refer to sequence codes in Table 1.
c
Estimation is based on the formula of Nei and Gojobori (39a).