TABLE 3.
Effect of mtrD and pilQ mutations on meningococcal strains with and without a deletion of ght
| Strain | Relevant genotype | Source | MIC (mg/liter) ofa:
|
||||
|---|---|---|---|---|---|---|---|
| Heme | ERY | AMP | TX100 | RIF | |||
| IR4048 | Parent strain | Clinical isolate | 125 | 2.0 | 0.125 | 125 | 0.125 |
| IR5700 | Δght | Δght IR5575 | 15 | 1.0 | 0.125 | 30 | 0.0075 |
| IR5721 | mtrD::Kanr | mtrD::kanr IR4048 | 125 | 0.125 | 0.125 | 60 | <0.003 |
| IR5725 | Δght mtrD::Kanr | mtrD::kanr IR5700 | 30 | 0.125 | 0.125 | 30 | 0.0075 |
| IR5749 | pilQ::Cmr | pilQ::cmr IR4048 | 125 | 2.0 | 0.125 | 125 | 0.06 |
| IR5751 | Δght pilQ::Cmr | pilQ::cmr IR5700 | 15 | 1.0 | 0.125 | 30 | 0.003 |
a
ERY, erythromycin; AMP, ampicillin; TX100, Triton X-100; RIF, rifampin. Results are mean values from three evaluations.