TABLE 1.

S. aureus genes up-regulated by ArlR

N315 ORF	N315 gene	N315 description	Change in expression level (n-fold)a	agr, sar, rot, or sigB effectb
SA1844	agrA	Response regulator	−2.8
SA1842	agrB	Accessory gene regulator B	−2.2
SA1843	agrC	Sensor histidine kinase	−2.4
SAS066	agrD	AgrD protein	−1.6
SA1248	arlR	Response regulator	−602.2
SAS065	hld	Delta-hemolysin	−2.2	agr +
SA0250	lytS	Two-component sensor histidine kinase	−3.1	rot +
SA0251	lytR	Two-component response regulator	−2.2
SA0144	cap5A	Capsular polysaccharide synthesis enzyme Cap5A	−1.8	σB +
SA0147	cap5D	Capsular polysaccharide synthesis enzyme Cap5D	−1.5	σB +
SA0211		Putative oxidoreductase	−2.1
SA0212		Hypothetical protein	−1.9
SA0220		Hypothetical protein	−2.8	rot +
SA0252	lrgA	Holin-like protein LrgA	−16.5	sar +, sigB −
SA0253	lrgB	Holin-like protein LrgB	−19.7	sar +, sigB −
SA0269		Hypothetical protein	−2.3
SA0270	ssaA	Secretory antigen precursor SsaA	−2	sigB
SA0271		Hypothetical protein	−5.9	agr +, rot +,
SA0272		Hypothetical protein	−7.4	sigB −
SA0275		Hypothetical protein	−4.2	sigB −
SA0276		Similar to diarrheal toxin	−4.4
SA0417		Hypothetical protein	−2.5
SA0519	sdrC	Ser-Asp-rich fibrinogen-binding protein SdrC	−2.3	sar +, rot +
SA0520	sdrD	Ser-Asp-rich fibrinogen-binding protein SdrD	−3.7
SA0521	sdrE	Ser-Asp-rich fibrinogen-binding protein SdrE	−2.1
SA0746		Staphylococcal nuclease	−1.9
SA0893		Hypothetical protein	−1.9
SA1269		Blt-like protein	−3.1
SA1270		Similar to amino acid pearmease	−1.8
SA1271		IlvA threonine deaminase	−3
SA1272		Alanine dehydrogenase	−2.4
SA1305		Cell-dividion initiation protein	−4.9
SA1583	rot	Repressor of toxin	−1.9
SA2222		Bicyclomycin-resistant protein TcaB	−2
SA2303		Hypothetical protein	−11.2	rot +
SA2486		2-Oxoglutarate/malate translocator	−1.8

^aNormalized values in the wild-type strain over values in the arlR mutant.

^bagr and sar effects are as described by Dunman et al. (13), rot effect is as described by Said-Salim et al. (41), and sigB effect is as described by Bischoff et al. (4). +, up-regulated; −, down-regulated.