Table 2.
Comorbidities in elder patients with and without seizure-freedom
| Seizure-freedom | Without seizure-freedom | χ2 | v | P-value | crude OR | 95% CI | P-value | adj. OR | 95% CI | P-value | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||||||||
| At least one comorbidity | 51 | 40.8% | 74 | 59.2% | 4.306 | 1 | 0.038* | 2.374 | 1.035–5.448 | 0.041* | 2.104 | 0.880–5.032 | 0.094 |
| Number of comorbidities | |||||||||||||
| 0 | 18 | 62.1% | 11 | 37.9% | 5.748 | 3 | 0.125 | 1.405 | 1.054–1.872 | 0.020* | 1.336 | 0.987–1.808 | 0.061 |
| 1 | 17 | 48.6% | 18 | 51.4% | |||||||||
| 2 | 14 | 41.2% | 20 | 58.8% | |||||||||
| ≥ 3 | 20 | 35.7% | 36 | 64.3% | |||||||||
| Comorbidity type | |||||||||||||
| Neurological | 35 | 37.2% | 59 | 62.8% | 5.591 | 1 | 0.018* | 2.204 | 1.139–4.265 | 0.019* | 1.705 | 0.844–3.443 | 0.137 |
| Traumatic brain injury | 7 | 35.0% | 13 | 65.0% | 0.894 | 1 | 0.345 | 1.599 | 0.600–4.259 | 0.348 | 1.441 | 0.520–3.997 | 0.482 |
| Intracranial tumors | 3 | 30.0% | 7 | 70.0% | 0.416 | 1 | 0.519 | 1.974 | 0491–7.940 | 0.338 | 1.913 | 0.434–8.443 | 0.392 |
| Dementia | 10 | 38.5% | 16 | 61.5% | 0.509 | 1 | 0.476 | 1.368 | 0.577–3.243 | 0.477 | 1.379 | 0.558–3.410 | 0.487 |
| Parkinson's Disease | 2 | 33.3% | 4 | 66.7% | 0.025 | 1 | 0.875 | 1.654 | 0.294–9.312 | 0.568 | 3.997 | 0.609–26.240 | 0.149 |
| Alcoholic encephalopathy | 0 | 0.0% | 4 | 100.0% | 1.733 | 1 | 0.188 | Ne | - | Ne | - | - | |
| Cerebrovascular disease | 23 | 44.2% | 29 | 55.8% | 0.010 | 1 | 0.918 | 1.036 | 0.529–2.208 | 0.918 | 0.824 | 0.395–1.718 | 0.605 |
| Cerebral infarction | 9 | 32.1% | 19 | 67.9% | 2.219 | 1 | 0.136 | 1.919 | 0.807–4.566 | 0.140 | 1.635 | 0.654–4.086 | 0.292 |
| Cerebral hemorrhage | 9 | 56.3% | 7 | 43.8% | 0.946 | 1 | 0.331 | 0.598 | 0.211–1.699 | 0.335 | 0.404 | 0.123–1.324 | 0.135 |
| Cerebral vascular malformations | 5 | 62.5% | 3 | 37.5% | 0.447 | 1 | 0.504 | 0.468 | 0.108–2.033 | 0.311 | 0.462 | 0.088–2.415 | 0.360 |
| Psychiatric | 10 | 25.0% | 30 | 75.0% | 8.571 | 1 | 0.003** | 3.218 | 1.440–7.194 | 0.004** | 2.606 | 1.124–6.041 | 0.026* |
| Anxiety | 8 | 25.8% | 23 | 74.2% | 5.665 | 1 | 0.017* | 2.829 | 1.175–6.811 | 0.020* | 2.665 | 1.067–6.654 | 0.036* |
| Depression | 8 | 25.0% | 24 | 75.0% | 6.407 | 1 | 0.016* | 3.000 | 1.250–7.199 | 0.014* | 2.469 | 0.989–6.165 | 0.053 |
| Psychotic disorders | 0 | 0.0% | 2 | 100.0% | Fisher’s exact test | 0.502 | Ne | - | - | Ne | - | - | |
| Cardiovascular | 32 | 46.4% | 37 | 53.6% | 0.125 | 1 | 0.724 | 0.891 | 0.471–1.688 | 0.724 | 0.913 | 0.461–1.809 | 0.794 |
| Hypertension | 31 | 49.2% | 32 | 50.8% | 0.835 | 1 | 0.361 | 0.740 | 0.388–1.412 | 0.361 | 0.736 | 0.368–1.473 | 0.386 |
| Heart disease | 7 | 33.3% | 14 | 66.7% | 1.294 | 1 | 0.255 | 1.746 | 0.663–4.603 | 0.259 | 1.677 | 0.602–4.670 | 0.322 |
| Endocrine/metabolic | 10 | 32.3% | 21 | 67.7% | 2.471 | 1 | 0.116 | 1.936 | 0.842–4.449 | 0.120 | 1.953 | 0.816–4.672 | 0.133 |
| Diabetes | 6 | 26.1% | 17 | 73.9% | 3.831 | 1 | 0.050 | 2.625 | 0.974–7.077 | 0.057 | 2.516 | 0.890–7.114 | 0.082 |
| Osteoporosis | 5 | 55.6% | 4 | 44.4% | 0.104 | 1 | 0.504 | 0.632 | 0.163–2.451 | 0.507 | 0.767 | 0.190–3.103 | 0.710 |
| Respiratory | 2 | 33.3% | 4 | 66.7% | 0.025 | 1 | 0.875 | 1.654 | 0.294–9.312 | 0.568 | 1.759 | 0.279–11.080 | 0.547 |
| Neoplasms (Extracranial) | 2 | 40.0% | 3 | 60.0% | 0.000 | 1 | 1.000 | 1.226 | 0.199–7.550 | 0.826 | 1.271 | 0.178–9.097 | 0.811 |
| Others | 1 | 33.3% | 2 | 66.7% | 0.000 | 1 | 1.000 | 1.639 | 0.145–18.460 | 0.689 | 2.577 | 0.225–29.471 | 0.446 |
| At least one bidirectional comorbidity | 17 | 30.9% | 38 | 69.1% | 6.680 | 1 | 0.010* | 2.473 | 1.235–4.954 | 0.011* | 2.162 | 1.037–4.506 | 0.040* |
| Number of bidirectional comorbidities | |||||||||||||
| 0 | 51 | 52.0% | 47 | 48.0.% | Fisher’s exact test | 0.026* | 1.713 | 1.139–2.577 | 0.010* | 1.578 | 1.034–2.408 | 0.034* | |
| 1 | 12 | 42.9% | 16 | 57.1% | |||||||||
| 2 | 4 | 18.2% | 18 | 81.8% | |||||||||
| 3 | 2 | 33.3% | 4 | 66.7% | |||||||||
| At least one causal comorbidity | 32 | 39.50% | 49 | 60.50% | 1.94 | 1 | 0.164 | 1.574 | 0.830–2.983 | 0.165 | 1.265 | 0.632–2.532 | 0.506 |
| Number of causal comorbidities | |||||||||||||
| 0 | 37 | 50.70% | 36 | 49.30% | Fisher’s exact test | 0.125 | 1.457 | 0.780–2.721 | 0.237 | 1.157 | 0.588–2.278 | 0.673 | |
| 1 | 31 | 38.80% | 49 | 61.30% | |||||||||
| 2 | 1 | 100.00% | 0 | 0.00% | |||||||||
| At least one other comorbidity | 36 | 49.40% | 53 | 59.60% | 1.63 | 1 | 0.203 | 1.518 | 0.797–2.893 | 0.204 | 1.580 | 0.798–3.164 | 0.188 |
| Number of other comorbidities | |||||||||||||
| 0 | 33 | 50.80% | 32 | 49.20% | 2.25 | 3 | 0.522 | 1.254 | 0.892–1.761 | 0.192 | 1.293 | 0.900–1.857 | 0.164 |
| 1 | 21 | 41.20% | 30 | 58.80% | |||||||||
| 2 | 11 | 44.00% | 14 | 56.00% | |||||||||
| 3 + | 4 | 30.80% | 9 | 69.20% | |||||||||
*. P < 0.05; **. P < 0.01