Fig. 2.
a Representative iNOS immunoblots in protein extracts from the ascending aortas of P16 WT and Fbn1mgR/mgR (MFS) mice with quantitative plots shown on the bottom. GAPDH was used as a loading control. b ACh-dependent vasorelaxation assessed in aortic ring isolated from Fbn1mgR/mgR mice (MFS) and WT littermates before and after incubation with iNOS inhibitor, 1400W (n = 3 per genotype and treatment). c ACh-dependent vasorelaxation assessed in aortic ring isolated from Fbn1mgR/mgR mice (MFS) and WT littermates before and after incubation with nNOS inhibitor, NPA (n = 4 per genotype and treatment). Asterisks indicate statistical significance. NPA, N(ω)-propyl-l-arginine.
