TABLE 2.
Distribution of NTSFs in bacteria
| Speciesb | NTSF annotation(s)a | Biochemical function |
|---|---|---|
| Deep branching | ||
| Aquifex aeolicus (2)c | Two PAPs | TNT (CC and A addition) |
| Deinococcus radiodurans (2) | TNT, TNT/PAP | TNT (CC and A addition) |
| Thermotoga maritima (1) | TNT | TNT (CCA addition) |
| Cyanobacteria | ||
| Synechocystis sp. (2)c | Two PAPs | TNT (CC and A addition) |
| Nostoc sp. strain PCC 7120 (2) | Two PAPs | Unknown |
| HGC+ | ||
| Corynebacterium diphtheriae (1) | TNT | Unknown |
| Mycobacterium leprae (1) | PAP | Unknown |
| Mycobacterium tuberculosis (1) | PAP | Unknown |
| Streptomyces avermitilis (1) | PAP | Probable TNTd |
| Streptomyces coelicolor (1) | NTSF | TNT (CCA addition) |
| LGC+ | ||
| Bacillus anthracis (1) | PAP | Unknown |
| Bacillus cereus (1) | PAP | Unknown |
| Bacillus halodurans (2) | PAP, unknown NTSF | TNT (CC and A addition) |
| Bacillus subtilis (1) | PAP | TNT (CCA addition) |
| Bacillus stearothermophilus (1) | PAP | TNT (CCA addition) |
| Clostridium perfringens (1) | PAP | Unknown |
| Enterococcus faecalis (1) | PAP | Unknown |
| Lactobacillus plantarum (1) | PAP | Probable TNTe |
| Lactococcus lactis (1) | PAP | Unknown |
| Staphylococcus aureus (1) | PAP | Unknown |
| Streptococcus pyogenes (1) | PAP | Unknown |
| α-Proteobacteria | ||
| Agrobacterium tumefaciens (1) | PAP | Unknown |
| Bradyrhizobium japonicum (1) | PAP | Unknown |
| Brucella melitensis (1) | PAP/TNT | Unknown |
| Caulobacter crescentus (1) | PAP | Unknown |
| β-, γ-Proteobacteria | ||
| Bordetella pertussis (2) | TNT and PAP | Unknown |
| Chromobacterium violaceum (2) | TNT and PAP | Unknown |
| Neisseria meningitides (2) | TNT and PAP | Unknown |
| Escherichia coli (2) | TNT and PAP | TNT and PAP |
| Haemophilus influenzae (2) | TNT and PAP | Unknown |
| Pasteurella multocida (2) | TNT and PAP | Unknown |
| Pseudomonas aeruginosa (2) | TNT and PAP | Unknown |
| Salmonella enterica serovar Typhimurium (2) | TNT and PAP | Unknownf |
| Vibrio cholerae (2) | TNT and PAP | Unknown |
| Xanthomonas axonopodis (2) | TNT and PAP | Unknown |
| Xylella fastidiosa (2) | TNT and PAP | Unknown |
| Yersinia pestis (2) | TNT and PAP | Unknown |
| δ-Proteobacteria | ||
| Bdellovibrio bacteriovorus (2) | PAP, TNT/PAP | Unknown |
| Desulfovibrio vulgaris (2) | TNT, PAP family | Unknown |
| Geobacter sulfurreducens (3) | One PAP, two PAP family | Unknown |
| ɛ-Proteobacteria | ||
| Campylobacter jejuni (1) | NTSF | Unknown |
| Helicobacter pylori (1) | PAP | Unknown |
| Wolinella succinogenes (1) | TNT | Unknown |
The annotation of the NTSFs in the genome database. In some cases the ORF is annotated as a TNT and in others as a PAP. Some annotations describe the NTSF as a member of the TNT/PAP or PAP family, and others list it as an unknown NTSF.
The numbers in parentheses after the species names indicate the number of NTSFs in the genome of that species.
The functions of the NTSFs from A. aeolicus, D. radiodurans, T. maritima, and Synechocystis spp. have been determined.
Based on the sequence similarity between the S. avermitilis and S. coelicolor NTSFs, the former NTSFI is thought to be a TNT.
The NTSF of Lactobacillus acidophilus is a TNT (19).
E. coli pcnB hybridizes to a DNA fragment from S. enterica serovar Typhimurium (10).