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Enpp1-deficient mice showed a significant increase in ossification of PLL after 8 weeks of hypermobility. (A, B) micro-CT sagittal and axial images of heterotopic ossification, n = 6, red arrows represent ossification formation in different regions. (C) Quantitative analysis of the relative cross-sectional area of bone masses in the cervicothoracic spinal canal of mice, n = 6, all data are expressed as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001.
