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. 2025 Mar 19;16:1561199. doi: 10.3389/fphys.2025.1561199

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Copyright © 2025 Tang, Zhu, He, Wang, Chen, Li, Chen, Zhou, Wang, Liu, Yao, Liu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Weight changes and HE staining which subjected to spinal hypermobility. (A) The changes in body weight of mice were assessed under varied stimulation periods in the control group, slow hypermobility (SH) group and fast hypermobility (FH) group, all data are expressed as mean ± SD. (B–E) After stimulation for 4, 8, 12, and 24 weeks, images of the sagittal and axial mouse spine stained with HE is shown, with red boxes representing the production of heterotopic ossification. (F) Quantitative analysis was performed to assess the ossification range of PLL in the mobility group compared to the control group using HE staining. n = 6, *p < 0.05, **p < 0.01, ***p < 0.001.