Table 2.
Results of meta-analysis for all clinical outcomes.
| Outcomes | No. of studies | Sample size | Heterogeneity | Overall effect size | 95% CI of overall effect | P-value | ||
|---|---|---|---|---|---|---|---|---|
| VA | BQT | I2 (%) | P-value | |||||
| H. pylori eradication rate (ITT) | 17 | 1,443 | 1,451 | 62 | <0.01 | RR = 1.07 | 1.01 ~ 1.12 | 0.01 |
| H. pylori eradication rate (PP) | 17 | 1,369 | 1,324 | 5 | <0.01 | RR = 1.03 | 0.99 ~ 1.08 | 0.13 |
| Overall AEs | 16 | 1,310 | 1,309 | 0 | 0.99 | RR = 0.43 | 0.37 ~ 0.51 | <0.01 |
| Compliance | 17 | 1,440 | 1,444 | 46 | 0.02 | RR = 1.03 | 1.01 ~ 1.05 | <0.01 |
| Nausea and/or vomiting | 15 | 1,236 | 1,232 | 4 | 0.41 | RR = 0.38 | 0.26 ~ 0.55 | <0.01 |
| Diarrhea | 14 | 1,207 | 1,210 | 4 | 0.39 | RR = 0.75 | 0.55 ~ 1.03 | 0.08 |
| Skin rash | 10 | 833 | 831 | 6 | 0.64 | RR = 0.76 | 0.42 ~ 1.38 | 0.36 |
| Dizziness and/or headaches | 7 | 777 | 777 | 0 | 0.65 | RR = 0.33 | 0.13 ~ 0.84 | 0.02 |
| Abdominal distension | 7 | 489 | 496 | 0 | 0.76 | RR = 0.75 | 0.43 ~ 1.30 | 0.31 |
| Abdominal pain | 8 | 830 | 832 | 0 | 0.70 | RR = 0.97 | 0.57 ~ 1.63 | 0.89 |
| Taste problem | 10 | 690 | 692 | 0 | 0.46 | RR = 0.10 | 0.05 ~ 0.17 | <0.01 |
| Constipation | 5 | 380 | 378 | 0 | 0.70 | RR = 0.75 | 0.26 ~ 2.13 | 0.59 |