TABLE 3.

MICs of CS-023 and comparators against E. coli JM109 and its transformants having a plasmid encoding a β-lactamase gene

Compound	MIC (μg/ml) against E. coli JM109 producing plasmid (β-lactamase type encoded):
	None	pTEM-1 (TEM-1)	pTEM-2 (TEM-2)	pTEM-3 (TEM-3)	pTEM-5 (TEM-5)	pTEM-9 (TEM-9)	pSHV5a (SHV-12)	pMTY010 (Toho-1)
CS-023	0.008	0.016	0.016	0.016	0.016	0.016	0.016	0.06
Imipenem	0.06	0.12	0.12	0.12	0.12	0.12	0.12	0.25
Meropenem	0.016	0.016	0.016	0.016	0.016	0.016	0.016	0.06
Cefotaxime	0.06	0.06	0.06	16	4	4	8	16
Ceftazidime	0.25	0.25	0.5	32	64	>128	64	64
Ceftriaxone	0.06	0.06	0.06	>128	16	32	32	>128
Ampicillin	4	>128	>128	>128	>128	>128	>128	>128
Amikacin	2	2	2	2	2	2	2	0.5
Levofloxacin	0.12	0.12	0.12	0.12	0.12	0.12	0.12	0.12