FIG. 3.
Effect of moxifloxacin exposures higher than the breakpoint AUC0-24/MIC ratio associated with suppression of resistance. The figure shows the effect of a non-protein-bound moxifloxacin AUC0-24/MIC ratio of 101.6 administered daily for 10 days in our in vitro pharmacodynamic model of TB. The solid line indicates the decline of the total Mycobacterium tuberculosis population, while the dashed line indicates that the resistant subpopulation remains below baseline during 10 days of therapy. (Reprinted from reference 10 with permission of the publisher.)