TABLE 3.
MIC values for inhibitors of efflux pumps against AG100, AG100A (acrAB deleted), AG100TET, and AG100ATETa
| Inhibitors | MIC (mg/liter)
|
|||
|---|---|---|---|---|
| AG100 | AG100A | AG100TET | AG100ATET | |
| Calcium channel | ||||
| CPZ | 60 | 20 | 140 | 120 |
| TZ | 100 | 25 | >200 | 100 |
| RES | 140 | 140 | 100 | 100 |
| VP | >3,000 | 450 | >3,000 | >3,000 |
| Proton pumps | ||||
| OM | >2,500 | >2,500 | >2,500 | >2,500 |
| CCCP | 10 | 10 | 20 | 20 |
| PAN | >200 | 50 | >200 | >200 |
a
The maximum solubility in the medium for some of the agents was reached with no effect on growth. Hence the MIC was arbitrarily identified as “greater than.” Calcium channel inhibitors: chlorpromazine (CPZ), thioridazine (TZ), reserpine (RES), and verapamil (VP). Proton pump inhibitors: omeprazole (OM), carbonyl cyanide m-chlorophenylhydrazone (CCCP), and Phe-Arg-napthylamide (MC-207,110) (PAN).