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. Author manuscript; available in PMC: 2026 Jan 24.
Published in final edited form as: Am J Drug Alcohol Abuse. 2025 Jan 24;51(1):127–136. doi: 10.1080/00952990.2025.2450416

Table 2.

Knowledge of Pharmacotherapies by Substance Use History

Full Sample History of Illicit
Substance Use
No History of Illicit
Substance Use
χ2 (p=)
Medication Name n (%)
Brand Name
 Suboxone 123 (39.2) 80 (51.3) 43 (27.2) 19.08 (p<0.001)
 Subutex 71 (22.6) 51 (32.7) 20 (12.7) 18.01 (p<0.001)
 Vivitrol 74 (23.6) 45 (28.8) 29 (18.4) 4.78 (p=0.03)
 Revia 41 (13.1) 27 (17.3) 14 (8.9) 4.93 (p=0.03)
 Narcan 156 (49.7) 86 (55.1) 70 (44.3) 3.68 (p=0.06)
 Methadone 204 (65.0) 106 (68.4) 98 (62.0) 1.40 (p=0.24)
 Buprenorphine 82 (21.7) 61 (39.1) 21 (13.3) 27.10 (p<0.001)
 Naltrexone 68 (21.7) 46 (29.5) 22 (13.9) 11.21 (p<0.001)
 Naloxone 84 (26.8) 56 (35.9) 28 (17.7) 13.23 (p<0.001)

Note. Chi-Square analyses were conducted to assess differences in knowledge of specific pharmacotherapies based on substance use history. Bolded text indicates significant difference between groups (those with a history of substance and those with no such history), p<0.05. Individuals with a history of substance use were more knowledgeable of all individual medications than those without a history of substance use, except for Narcan and Methadone, for which there were no group differences.