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Effect of TAK-220 on anti-CCR5 MAb binding to CCR5-expressing cells. MOLT-4/CCR5 cells were incubated in the presence of TAK-220 (100 nM) and examined for the binding of anti-CCR5 MAbs. MAbs 45531.111 and 2D7 recognize ECL2 of CCR5, while MAb 3A9 recognizes the N terminus (N-term.) of CCR5. The MFI obtained in the absence of compound was regarded as 100% binding of each MAb. The data are expressed as the means ± SDs of three separate experiments.
