TABLE 1.

Inhibitory effect of TAK-220 on HIV-1 envelope-mediated membrane fusion

Compound	IC50 (nM)a
	JR-FL (R5)	HXB2 (X4)
TAK-220	0.42 ± 0.17b	>1,000
AMD-3100	>1,000	34 ± 3.6

^aConcentrations of the test compounds required to inhibit membrane fusion by 50%.

^bAssays were performed in triplicate, and data are expressed as the means ± SDs of three separate experiments.