TABLE 5.
Anti-HIV-1 activity of TAK-220 in PBMCs from eight different donorsa
| Donor no. | p24 level (ng/ml) | EC50 (nM) | EC90 (nM) |
|---|---|---|---|
| 1 | 21 | 0.36 | 5.1 |
| 2 | 8.1 | 0.46 | 5.8 |
| 3 | 8.2 | 1.3 | 5.3 |
| 4 | 3.9 | 0.24 | 6.6 |
| 5 | 0.47 | 1.6 | 12 |
| 6 | 68 | 2.5 | 13 |
| 7 | 20 | 0.38 | 6.6 |
| 8 | 69 | 0.17 | 7.3 |
a
Cells were infected with R5 HIV-1 (JR-FL) and then incubated in the presence of various concentrations of TAK-220. The anti-HIV-1 activity was determined by measurement of p24 antigen levels on day 7 after virus infection. Assays were performed in triplicate wells.