TABLE 6.
Anti-HIV-1 activity of TAK-220 against recombinant HIV-1 expressing different subtype envelope glycoproteins
| Tropism | Subtype and sample no. | EC50 (nM)
|
|
|---|---|---|---|
| U87.CD4.CCR5 | U87.CD4.CXCR4 | ||
| R5 | A_R5_1 | 2.9a | NRb |
| A_R5_2 | 14 | NR | |
| A_R5_3 | 5.7 | NR | |
| B_R5_1 | 10 | NR | |
| B_R5_2 | 7.1 | NR | |
| B_R5_3 | 1.3 | NR | |
| B_R5_4 | 7.2 | NR | |
| B_R5_5 | 12 | NR | |
| B_R5_6 | 7.0 | NR | |
| B_R5_7 | 10 | NR | |
| B_R5_8 | 16 | NR | |
| B_R5_9 | 13 | NR | |
| B_R5_10 | 34 | NR | |
| C_R5_1 | 14 | NR | |
| C_R5_2 | 7.4 | NR | |
| C_R5_3 | 4.5 | NR | |
| D_R5_1 | 1.1 | NR | |
| E_R5_1 | 1.5 | NR | |
| E_R5_2 | 23 | NR | |
| E_R5_3 | 6.4 | NR | |
| F_R5_1 | 8.0 | NR | |
| F_R5_2 | 5.5 | NR | |
| F_R5_3 | 6.0 | NR | |
| R5X4 | B_Dual_1 | 7.0 | >19,000 |
| B_Dual_2 | 6.3 | >19,000 | |
| B_Dual_3 | 1.1 | >19,000 | |
| Overall mean | 8.9 | ||
| X4 | B_X4_1 | NR | >19,000 |
| B_X4_2 | NR | >19,000 | |
| B_X4_3 | NR | >19,000 | |
| D_X4_2 | NR | >19,000 | |
a
Data are expressed as the means of two separate experiments.
b
NR, not replicable.