TABLE 7.
Pharmacokinetics of TAK-220 after single oral administration in rats and monkeysa
| Parameter | Rat (n = 3) | Monkey (n = 4) |
|---|---|---|
| i.v./oral doses (mg/kg) | 1/5 | 1/5 |
| Bioavailability (%)b | 9.5 ± 3.8 | 28.9 ± 8.3 |
| i.v. AUC0-24c (ng · h/ml) | 141.0 ± 27.8 | 367.2 ± 48.2 |
| Oral Cmax (ng/ml) | 31.2 ± 8.1 | 298.0 ± 169.0 |
| Tmax (h) | 0.083 ± 0.0 | 0.7 ± 0.4 |
| Oral AUC0-24 (ng · h/ml) | 67.1 ± 23.7 | 538.3 ± 204.1 |
a
TAK-220 was administered orally or intravenously (i.v.) to fasted animals. Data are expressed as the means ± SDs.
b
Bioavailability = (AUCoral/AUCi.v.) × (dosei.v./doseoral) × 100. SD of bioavailability = bioavailability × [(SD of AUCoral/AUCoral)2 + (SD of AUCi.v./AUCi.v.)2]1/2.
c
AUC0-24, AUC from time zero to 24 h.