Figure 1.

Expression of Fxr1p in mouse and frog. Immunoblot analyses of Fxr1p in selected tissues of adult mouse (left) and adult Xenopus (right). Antibody mAb3FX is directed against an epitope common to all Fxr1p isoforms from both mouse and frog, whereas #27-17 is directed against the 27-amino acid pocket coded by the exon 15 that also is present in Xenopus. Fmr1p is detected predominantly in brain extracts from both mouse and frog. Note the cross-reactivity between mAb1C3 and Fxr1p in mouse heart and muscle as described previously (Khandjian et al., 1998; Chemicon International information sheet, MAB2160). H, heart; B, brain; M, muscle; L, liver; and K, kidney.