Table 1.

The roles of Plin5 in diabetes-related target organs

	Plin5 status	pathway	changed	Reference
Fat	Plin5 phosphorylation	Cold stimulates lipolysis↑	Browning of white fat cells↑	[49, 66]
skeletal muscle	Plin5 expression	Lipid droplet decomposition and synthesis	insulin sensitivity↑	[67]
liver	Plin5 deficiency	JNK-p38-ATF pathway	Impaired insulin signal transduction↑	[55, 68]
pancreas	Plin5 overexpression	PI3K/Akt pathway↑, ERK pathway↑	apoptosis↓, oxidative stress↓, Lipotoxicity of β-cells↓	[69, 70]
heart	MHC-Plin5 mice	Plin5 interacted with SERCA2↑, calcium treatment↑	Myocyte contractility↑, Left ventricular mass and myocardial cell size↑, Heart function is preserved	[71]
sertoli cell	Plin5 overexpression	Akt/GSK-3β/ NRF2 pathway↑	Apoptosis↓, Oxidative stress and inflammation↓, sertoli cell injury↓	[72]
blood vessel	ApoE(−/−)Plin5(-/-)	PI3K/AKT and MAPKs pathway↑, NF-κB pathway↑	Oxidative stress and inflammation↑, Lesion of capillary structure and function↑	[73, 74]