Fig 1.
Target attainment of amikacin for the first dose for neonates receiving the simplified dosing regimen or the complex dosing regimen per dosing category and in total. Target attainment is calculated for different targets for efficacy and toxicity, including peak concentrations (Cmax), area under the curve over minimum inhibitory concentration (AUC/MIC) for bacteriostasis or reduction, and trough concentrations (Cmin). The optimized pharmacokinetic model as described was used to calculate precise Cmin, Cmax, and AUC values at the first dose.