TABLE 1.

Complex model-derived dosing regimen of amikacin in neonates based on postnatal age and current body weight; in case of ibuprofen co-administration, the dosing interval is prolonged with 10 hours (2, 9)

Postnatal age (days)	Group	Current weight (grams)	Amikacin dose
<14	1	<800	16 mg/kg every 48 hours
	3	800 to 1,200	16 mg/kg every 42 hours
	5	1,200 to 2,000	15 mg/kg every 36 hours
	7a	2,000 to 2,800	15 mg/kg every 30 hours
	9a	>2,800	15 mg/kg every 24 hours
≥14	2	<800	20 mg/kg every 42 hours
	4	800 to 1,200	20 mg/kg every 36 hours
	6	1,200 to 2,000	18 mg/kg every 30 hours
	8	2,000 to 2,800	18 mg/kg every 24 hours
	10	>2,800	18 mg/kg every 20 hours

^a An additional prolonged dosing interval of +6 hours is suggested for subgroups 7 and 9 in the original publication (9). Since amikacin plasma concentrations were measured without this extended interval, the dosing regimen as listed in this table is used for the current evaluation.