Table 2.
P Values Obtained by Regression Analyses of Interactions of IL13 and IL4 SNPs with Eight IL4RA SNPs for Susceptibility to T1D[Note]
|
IL4RA SNP (dbSNP) |
||||||||
| Gene and SNP (dbSNP) | 5′ 3223(rs2057768) | I50V(rs1805010) | E375A(rs1805011) | C406R(rs1805012) | S411L(rs1805013) | S478P(rs1805015) | Q551R(rs1801275) | S761P(rs1805014) |
| IL4: | ||||||||
| 5′ −524 (rs2243250) | .92 | .56 | .98 | .96 | .45 | .93 | .61 | .55 |
| IL13: | ||||||||
| 5′ −1512 (rs1881457) | .63 | .87 | .95 | .54 | .80 | .70 | .34 | .43 |
| 5′ −1112 (rs1800925) | .48 | .68 | .99 | .52 | .98 | .81 | .52 | .43 |
| +1923 (rs1295686) | .41 | .37 | .98 | .47 | .75 | .39 | .61 | .79 |
| R110Q (rs20541) | .38 | .43 | .26 | .53 | .64 | .35 | .62 | .45 |
Note.— Results are shown for a sample of 1,616 white patients. To correct for regional variation in allele frequencies, the analyses were stratified according to 12 broad geographical regions within Great Britain (D.G.C., unpublished data).