Table A3.
Estimated IL4RA Haplotype Frequencies in Controls and Patients with T1D[Note]
| Haplotypea | MAF in Controls/MAF in Patients with T1D | OR | 95% CI |
| 111111 | .4865/.4848 | .97 | .90–1.05 |
| 211111 | .4099/.4138 | Reference | … |
| 212122 | .0304/.0383 | .94 | .79–1.14 |
| 211222 | .0202/.0255 | 1.12 | .87–1.44 |
| 111112 | .0199/.0186 | .91 | .71–1.18 |
| 122122 | .0135/.0140 | 1.00 | .74–1.36 |
Note.— Data are for six SNPs: IL4RA I50V (rs1805010), E375A (rs1805011), C406R (rs1805012), S411L (rs1805013), S478P (rs1805015), and Q551R (rs1801275). SNP S761P (rs1805014) was excluded from analysis because of low MAF. To correct for regional variation in allele frequencies, the analyses were stratified according to 12 broad geographical regions within Great Britain (D.G.C., unpublished data).
a
Haplotypes with MAF >0.01 are shown. “1” denotes the presence of the reference allele, and “2” denotes the presence of the variant allele for each SNP.