Table 3.

Pseudomarker Analysis of SNPs TYK2 rs2304256 and IRF5 rs2004640 in the Swedish, Finnish, and Icelandic Populations, in Dominant and Recessive Models^[Note]

	P Valuesa for
	Joint Linkage and Association				Linkage Only
Model anddbSNP rs Number	Sweden	Finland	Icelandb	Combinedc	Sweden	Finland	Iceland	Combinedc
Dominant:
TYK2 rs2304256	1.0×10-6	.018	4.1×10-3	2.2×10-8	.23	.23	.063	.077
IRF5 rs2004640	8.5×10-5	1.5×10-4	.015	5.2×10-8	.50	.35	5.4×10-3	.031
Recessive:
TYK2 rs2304256	2.5×10-5	6.0×10-4	.054	2.0×10-7	.50	.17	.32	.30
IRF5 rs2004640	8.1×10-4	4.1×10-4	.25	1.2×10-5	.50	.42	.3	.49

Note.— The P values obtained in a dominant model in the Swedish and Finnish populations are identical to the values in table 2. The combined P values in the Swedish and Finnish populations were 3.4×10^-7 for TYK2 rs2304256 and 2.4×10^-7 for IRF5 rs2004640 in a dominant model (table 2) and were 2.8×10^-7 for TYK2 rs2304256 and 5.2×10^-6 for IRF5 rs2004640 in a recessive model.

^aP values are unadjusted for multiple testing.

^bIn the Icelandic patients with SLE, the frequency of the minor allele (C allele) of IRF5 rs2004640 was .43, and that of the minor allele (A allele) of TYK2 rs2304256 was .14.

^cFisher’s procedure for combination of P values from different data sets was used to derive overall P values, by use of the analytical expression of Jost.