Table 2.
Initial Analysisa |
Follow-Up Analysisb |
Combined Analysisc |
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Chromosome | Marker or Interval | NPL | P | HLOD | α (%) | NPL | P | HLOD | α (%) | NPL | P | HLOD | α (%) | Genetic Modeld |
1p36 | D1S2674–D1S2885 | 2.67 | .0045 | 1.08 | 21 | .98 | .16 | .09 | 4.5 | 2.37 | .0093 | 1.17 | 11 | Rec |
4q13-q21 | D4S1592–D4S1534 | 2.94 | .0021 | 1.94 | 28 | 4.29 | .00001 | 2.74 | 35 | 4.62 | .000003 | 4.01 | 31 | Rec |
6p21-p22 | D6S289–D6S291 | 2.68 | .0044 | 2.26 | 37 | 2.17 | .016 | 1.32 | 45 | 3.16 | .00092 | 2.14 | 32 | Dom |
6q24-q25 | D6S308–D6S441 | 3.05 | .0017 | 2.99 | 36 | 1.27 | .11 | .31 | 11 | 2.98 | .0016 | 1.37 | 16 | Rec |
14q12-q13 | D14S70 | 2.83 | .0026 | 2.15 | 48 | .048 | .48 | 0 | 0 | 2.17 | .014 | 1.51 | 34 | Dom |
22q12 | D22S280–D22S283 | 2.87 | .0023 | 1.55 | 33 | .47 | .32 | .0066 | .038 | 1.75 | .039 | .72 | 19 | Dom |
Performed by analyzing 382 microsatellite markers in 57 multiplex Chinese families.
Performed by analyzing various numbers of markers in 49 multiplex Chinese families.
Performed by analyzing various numbers of markers in 106 multiplex Chinese families.
Rec = recessive inheritance; Dom = dominant inheritance.