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Impact of the number of flanking markers. Results are based on 2,000 replicates of 500 ASPs simulated under an additive model with population disease prevalence K = 2%, allele frequency pD=pA=0.15, and sibling recurrence-risk ratios λs=1.1 (A) and 1.3 (B). Data were simulated using 10 flanking markers, each with two equally frequent alleles. Intermarker recombination fraction is 0.1. Power was assessed at the 5% level.
