Table 1.
MIC1 values for JNJ-2901 on two reference strains and 18 multi-drug-resistant clinical strains with different antibiotic resistance profiles
| Strain | MICa (μg/L) | Resistance profile |
|---|---|---|
| H37Rv Pasteur | >8 | n.a. |
| Erdman | >8 | n.a. |
| 661706043123 | ≤0.5 | INH, PAS |
| 661710016056 | ≤0.5 | INH, S, PAS |
| 661904036200 | ≤0.5 | INH, PAS |
| 662003052840 | ≤0.5 | INH, EMB, PZA, S, CYC, PAS, ETH |
| 662012006551 | ≤0.5 | INH, PAS, PZA, ETH (LNZ geno) |
| 662101040833 | ≤0.5 | INH, RIF, PZA, S, PAS, EMB, ETH, KAN, CAP, AMK, CYC |
| 662105041666 | ≤0.5 | INH, RIF, S, PZA, EMB, FQL, ETH, CYC, PAS |
| 662108038389 | ≤0.5 | INH, RIF, S, PAS |
| 661906047849 | ≤0.5 | INH, RIF, S, PZA, ETH, PAS, EMB, CYC |
| 661907010966 | ≤0.5 | INH, RIF, S, PAS, EMB, PZA, CYC, AMK, KAN, CAP, ETH |
| 661908012994 | ≤0.5 | INH, RIF, S, PZA, PAS, ETH |
| 661911031781 | ≤0.5 | INH, RIF, S, PAS, CYC, ETH, KAN |
| 661911038007 | ≤0.5 | INH, RIF, S, PAS |
| 662004032055 | ≤0.5 | INH, RIF, S, PAS, ETH |
| 662001006107 | ≤0.5 | INH, RIF, PZA, S, PAS, CYC, ETH, FQL |
| 662001071666 | ≤0.5 | INH, RIF, S, PAS, PZA, EMB, ETH |
| 662001039167 | ≤0.5 | INH, RIF, S, PAS, EMB, PZA, CYC, KAN |
| 662008015398 | ≤0.5 | INH, RIF, S, PAS, EMB, PZA, ETH |
INH isoniazid, RIF rifampicin, S streptomycin, PAS para-aminosalicylic acid, EMB ethambutol, PZA pyrazinamide, CYC cycloserin, ETH ethionimide, KAN kanamycin, CAP capreomycin, AMK amikacin, FQL fluoroquinolone, LNZ linezolid.
Minimum Inhibitory Concentration is defined as the concentration of inhibitor where <1% of the inoculum is able to grow.