Table 3.
JNJ-2901 resistance mutations
| Subunit | Mutation in Mtb | M. smegmatis residue | Mutant protein |
|---|---|---|---|
| QcrB | A317V | A312 | A312V |
| QcrB | M342T | M337 | M337V |
| QcrA | L356W | L349 | L349W |
List of mutations in Mtb H37Rv-ΔcydAB that give rise to resistance against JNJ-2901.
JNJ-2901 resistance mutations
| Subunit | Mutation in Mtb | M. smegmatis residue | Mutant protein |
|---|---|---|---|
| QcrB | A317V | A312 | A312V |
| QcrB | M342T | M337 | M337V |
| QcrA | L356W | L349 | L349W |
List of mutations in Mtb H37Rv-ΔcydAB that give rise to resistance against JNJ-2901.