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. 2025 Mar 22;30(3):299–309. doi: 10.1007/s00775-025-02111-2

Table 2.

Top associated genes with AD

Rank Gene Name Normalized association
1 APP Amyloid Precursor Protein 89%
2 APOE Apolipoprotein E 83%
3 PSEN1 Presenilin 1 80%
4 MAPT Microtubule Associated Protein Tau 79%
5 BACE1 β-secretase 1 78%
6 SNCA α-synuclein 73%
7 PSEN2 Presenilin 2 72%
8 BDNF Brain-derived neurotrophic factor 71%
9 ACHE Acetylcholinesterase 71%
10 BCHE Butyrylcholinesterase 70%